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Sound Source Localization Testing in Single-sided Deafness Following Bone Conduction Intervention
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Topological reorganization after partial auditory deprivation-a structural connectivity study in single-sided
Xuesong Li1, Yufei Qiao2, Hang Shen3
1School of Computer Science and Technology, Beijing Institute of Technology, Beijing, People's Republic of China.
Hearing Research
|June 15, 2019
Summary
Individuals with single-sided deafness (SSD) exhibit altered brain connectivity, with stronger connections in cognitive networks correlating with better hearing abilities. This reveals significant white matter reorganization following partial auditory deprivation.
Area of Science:
- Neuroscience
- Auditory Neuroscience
- Neuroimaging
Background:
- Partial auditory deprivation, such as single-sided deafness (SSD), induces neural plasticity beyond the auditory cortex.
- Structural brain connectome alterations in SSD and their link to auditory function remain under-investigated.
Purpose of the Study:
- To investigate white matter structural connectivity changes in long-term single-sided deafness.
- To explore the relationship between structural connection strength and auditory abilities in SSD patients.
Main Methods:
- Diffusion tensor imaging (DTI) was employed to analyze white matter structural connectivity.
- Network-based statistical analysis was used to compare SSD individuals with normal hearing controls.
Main Results:
- Single-sided deafness (SSD) showed globally enhanced connection efficiency.
- Local visual networks were weakened, while fronto-parietal sub-networks were strengthened in SSD.
- A significant positive correlation was observed between hearing abilities (speech recognition in noise, sound localization) and fronto-parietal connection strength in SSD.
Conclusions:
- Single-sided deafness (SSD) leads to significant alterations in the brain's structural network connections, particularly in cognitive networks.
- The observed changes in white matter connectivity are closely related to residual hearing abilities in SSD.
- These findings offer novel insights into the brain's topological white matter reorganization in response to partial sensory deprivation.
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