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Related Experiment Video

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A Fluorescence-based Assay of Phospholipid Scramblase Activity

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Published on: September 20, 2016

Novel trisaccharide based phospholipids as immunomodulators.

Srinivasa Reddy Bonam¹, Debabrata Bhunia², Sylviane Muller³

¹Vaccine Immunology Laboratory, Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology (IICT), Hyderabad, 500007, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-IICT Campus, Hyderabad, 500007, India; UMR 7242 CNRS- Neuroimmunology & Peptide Therapy Team, University of Strasbourg, Biotechnology and cell signaling, Illkirch, France/Laboratory of excellence Medalis, Institut de science et d'ingénierie supramoléculaire (ISIS), 67000, Strasbourg, France.

International Immunopharmacology

|June 15, 2019

Summary

Novel glycophospholipids were synthesized and tested for immune system effects. Compound P4 showed significant immune-boosting and adjuvant properties, demonstrating potential for vaccine development.

Keywords:

Adjuvanticity Glycophospholipids Immunomodulators Innate immunity Mannosyl trisaccharide Vaccines

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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

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Published on: January 7, 2019

Area of Science:

Medicinal Chemistry
Immunology
Glycobiology

Background:

Mannosylated glycophospholipids are crucial in biological processes.
Understanding their interactions with immune receptors is key for therapeutic development.

Purpose of the Study:

To synthesize novel mannosylated glycophospholipids.
To evaluate their potential as immunomodulatory agents and vaccine adjuvants.

Main Methods:

Synthesis of glycophospholipids using imidate coupling and H-phosphate phosphorylation.
Molecular docking studies to predict receptor interactions.
In vitro and in vivo assays to assess immunomodulatory activity.

Main Results:

Compound P4 demonstrated specific binding to dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN).
P4 exhibited significant immunopotentiation and adjuvant properties, enhancing cytokine expression and ovalbumin-specific antibody titers.
The study identified PIMs analogues as promising candidates for vaccine applications.

Conclusions:

Novel mannosylated glycophospholipids, particularly P4, show potent immunomodulatory and adjuvant effects.
These compounds, derived from phosphatidylinositol mannosides (PIMs), hold promise for enhancing vaccine efficacy.
Tailored PIMs analogues could lead to novel molecules for diverse vaccine preparations.