Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Optimal Foraging00:48

Optimal Foraging

13.7K
How animals obtain and eat their food is called foraging behavior. Foraging can include searching for plants and hunting for prey and depends on the species and environment.
13.7K
Optimization Problems01:26

Optimization Problems

55
Optimization problems often involve identifying maximum or minimum values under specific constraints. A well-known example is determining the longest horizontal pipe that can be moved around a right-angled corner, where a 3-meter-wide hallway meets a 2-meter-wide hallway. This scenario, common in architectural design and industrial transport, can be understood conceptually through geometric and trigonometric reasoning.To visualize the problem, consider the pipe as a straight line that touches...
55
Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

1.6K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
1.6K
Types of Errors: Detection and Minimization01:12

Types of Errors: Detection and Minimization

10.8K
Error is the deviation of the obtained result from the true, expected value or the estimated central value. Errors are expressed in absolute or relative terms.
Absolute error in a measurement is the numerical difference from the true or central value. Relative error is the ratio between absolute error and the true or central value, expressed as a percentage.
Errors can be classified by source, magnitude, and sign. There are three types of errors: systematic, random, and gross.
Systematic or...
10.8K
Optimal Arousal Theory01:23

Optimal Arousal Theory

806
The optimal arousal theory suggests that performance is maximized when an individual experiences a moderate level of arousal. This theory is closely tied to the Yerkes-Dodson law, which illustrates an inverted U-shaped relationship between arousal and performance. The law, formulated by psychologists Robert Yerkes and John Dodson, implies an ideal arousal level for optimal performance, and deviations from this level can lead to declines in effectiveness.
Inverted U-Shaped Performance Curve
The...
806
Unrealistic Optimism Bias01:30

Unrealistic Optimism Bias

216
Unrealistic optimism bias is the tendency to overestimate the likelihood of positive outcomes. This cognitive bias makes individuals believe they are less likely to experience failures, setbacks, or risks and more likely to succeed than others. For example, people may assume they are less prone to health issues, accidents, or financial struggles than their peers, even when they share similar risk factors.One key component of this bias is the above-average effect, where individuals perceive...
216

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Criteria for the Definition of Refractory Septic Shock: A Joint Delphi Consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM).

Critical care medicine·2026
Same author

Clinical criteria for the definition of refractory septic shock: a joint Delphi consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM).

Intensive care medicine·2026
Same author

Long-Term Renal Outcomes Among COVID-19 ICU Survivors Admitted With Acute Kidney Injury.

Cureus·2025
Same author

Author Correction: Current standard of care for septic shock.

Intensive care medicine·2025
Same author

Current standard of care for septic shock.

Intensive care medicine·2025
Same author

European Society of Intensive Care Medicine Clinical Practice Guideline on fluid therapy in adult critically ill patients: Part 3-fluid removal at de-escalation phase.

Intensive care medicine·2025
Same journal

Genomic dynamics of antimicrobial resistance transmission between bacteria from intensive care unit surfaces and from critically ill patients.

Critical care (London, England)·2026
Same journal

Neutrophil EMR3 dynamics in critically ill patients with sepsis: an ICU experience.

Critical care (London, England)·2026
Same journal

Association between red blood cell transfusion volume and infection risk: a dose-response analysis of a nationwide trauma registry.

Critical care (London, England)·2026
Same journal

Interpreting protein dose trials in critical illness: a guide for the bedside clinician.

Critical care (London, England)·2026
Same journal

Multidisciplinary telemedicine intervention for ICU recovery: the TelePORT feasibility randomized trial.

Critical care (London, England)·2026
Same journal

Decoding candidemia in critically ill patients: unsupervised clustering identifies three unique phenotypes.

Critical care (London, England)·2026
See all related articles

Related Experiment Video

Updated: Jan 23, 2026

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
13:35

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites

Published on: March 1, 2018

15.3K

Minimizing catecholamines and optimizing perfusion.

Daniel De Backer1, Pierre Foulon2

  • 1Department of Intensive Care, CHIREC Hospitals, Université Libre de Bruxelles, Boulevard du Triomphe 201, B-1160, Brussels, Belgium. ddebacke@ulb.ac.be.

Critical Care (London, England)
|June 16, 2019
PubMed
Summary
This summary is machine-generated.

Catecholamines can improve cardiac output and blood pressure, but their effect on tissue perfusion in septic shock requires careful consideration of microcirculation impacts and alternative strategies. This review explores these options.

Keywords:
Cardiac outputFluid therapyInotropic agentsMicrocirculationVasopressor agents

More Related Videos

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
06:46

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse

Published on: July 25, 2025

1.0K
Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
09:38

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

943

Related Experiment Videos

Last Updated: Jan 23, 2026

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites
13:35

A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites

Published on: March 1, 2018

15.3K
Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse
06:46

Optimized Minimally Invasive Transscleral Subretinal Injection Technique in Mouse

Published on: July 25, 2025

1.0K
Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
09:38

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

943

Area of Science:

  • Critical Care Medicine
  • Pharmacology
  • Physiology

Background:

  • Catecholamines are commonly used to enhance cardiac output and blood pressure, aiming to improve tissue perfusion.
  • The effectiveness of catecholamines relies on parallel increases in regional organ perfusion and the absence of negative microcirculatory effects.
  • Inotropic agents may be beneficial but necessitate optimized cardiac preload.

Purpose of the Study:

  • To review the advantages and disadvantages of using catecholamines for improving tissue perfusion in septic shock.
  • To discuss alternative strategies for enhancing tissue perfusion in the context of septic shock.
  • To evaluate the role of vasodilatory agents in conjunction with vasopressors.

Main Methods:

  • Literature review of studies on catecholamine use in septic shock.
  • Analysis of physiological effects of catecholamines on cardiac output, blood pressure, and microcirculation.
  • Comparison of different therapeutic approaches for tissue perfusion optimization.

Main Results:

  • Catecholamines' impact on microcirculation can be variable and may not always translate to improved organ perfusion.
  • Minimizing vasopressor exposure while tolerating hypotension is a potential strategy if organ perfusion is maintained.
  • Combining moderate-dose vasopressors with vasodilators, particularly those acting on the microcirculation, presents an alternative approach.

Conclusions:

  • The use of catecholamines in septic shock requires a nuanced understanding of their effects beyond systemic hemodynamics.
  • Alternative strategies, including judicious vasopressor use and combination therapies, may offer improved tissue perfusion.
  • Further research is needed to optimize therapeutic interventions for septic shock-induced hypoperfusion.