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Published on: February 22, 2019
ILCs in hematologic malignancies: Tumor cell killers and tissue healers
Bianca Blom1, Vera van Hoeven1, Mette D Hazenberg2
1Department of Experimental Immunology, Amsterdam UMC location AMC, University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam and Amsterdam Institute of Infection and Immunity, Amsterdam UMC, Amsterdam, the Netherlands.
Abstract:
Innate lymphoid cells (ILCs) have attracted considerable attention in the past years. As modulators of epithelial barrier immunology and homeostasis they play important roles in (auto)immunity and inflammation. Here we review the role of ILCs in hematologic malignancies, where ILCs act as efficient killer cells and as tissue healers, in the context of chemotherapy, radiotherapy and after allogeneic hematopoietic stem cell transplantation (HSCT).
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