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Related Experiment Videos

Exocrine pancreatic function test by a synthetic peptide.

H Harada, K Mishima, T Shundo

    The American Journal of Gastroenterology
    |January 1, 1979
    PubMed
    Summary

    This study introduces a new test for exocrine pancreatic function using N-Benzoyl-L-tyrosyl-p-aminobenzoic acid. The test effectively detects moderate to severe pancreatic insufficiency by measuring urinary p-aminobenzoic acid recovery.

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    Area of Science:

    • Gastroenterology
    • Biochemistry
    • Diagnostic Medicine

    Background:

    • Exocrine pancreatic insufficiency (EPI) diagnosis requires reliable functional tests.
    • Current diagnostic methods may lack sensitivity for mild cases.
    • A simple, non-invasive test for pancreatic function is needed.

    Purpose of the Study:

    • To evaluate the diagnostic utility of a novel synthetic substance, N-Benzoyl-L-tyrosyl-p-aminobenzoic acid, as an exocrine pancreatic function test.
    • To assess the correlation of this test with established pancreatic function parameters.

    Main Methods:

    • Oral administration of N-Benzoyl-L-tyrosyl-p-aminobenzoic acid.
    • Measurement of urinary p-aminobenzoic acid (P.A.B.A.) recovery post-administration.
    • Comparison of P.A.B.A. recovery with secretin-cholecystokinin (P.Z./C.C.K.) stimulation test results.

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    Main Results:

    • Significant correlation observed between P.A.B.A. recovery and maximal bicarbonate concentration, amylase output, and secretin test volume.
    • Abnormal results typically require significant pancreatic resection (over 1/2 to 2/3 proximal or 1/3 distal).
    • High sensitivity (95.7%) for detecting EPI in cases with multiple abnormal P-S test factors, compared to lower sensitivity (54.5%) with one abnormal factor.

    Conclusions:

    • The N-Benzoyl-L-tyrosyl-p-aminobenzoic acid test is a simple and useful tool for detecting moderate to severe exocrine pancreatic insufficiency.
    • The test may yield normal results in cases of minimal to mild EPI.
    • The test's diagnostic accuracy is higher when correlated with multiple abnormal findings from established pancreatic function tests.