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Related Concept Videos

Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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CNS Stimulants: Cocaine, Amphetamines and Cannabinoids01:24

CNS Stimulants: Cocaine, Amphetamines and Cannabinoids

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CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Acupuncture in a Rat Model of Asthma
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[Asthma and cocaine use].

M Underner1, J Perriot1, G Peiffer1

  • 1Service de pneumologie, unité de tabacologie, centre hospitalier Henri Laborit, CHU La Milétrie, rue de la Milétrie, Pavillon René Beauchant, BP 577, avenue Jacques Cœur, 86021 Poitiers, France; Addictologie, dispensaire Emile Roux, 63100 Clermont-Ferrand, France; Pneumologie, centre hospitalier de Metz, Metz, France; Unité de recherche clinique, centre hospitalier Henri Laborit, 86021 Poitiers, France.

Revue Des Maladies Respiratoires
|June 16, 2019
PubMed
Summary
This summary is machine-generated.

Cocaine use is linked to new-onset asthma and severe exacerbations, sometimes requiring mechanical ventilation. Healthcare providers should consider cocaine use in asthma patients and encourage cessation.

Keywords:
AsthmaAsthmeBronchospasmBronchospasmeCocaineCocaïneCrackFreebase

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Area of Science:

  • Pulmonology
  • Toxicology
  • Addiction Medicine

Background:

  • Cocaine use is associated with various respiratory issues.
  • Asthma is a significant respiratory complication linked to cocaine consumption.

Purpose of the Study:

  • To systematically review existing literature on the relationship between asthma and cocaine use.
  • To understand the impact of cocaine on asthma onset and exacerbations.

Main Methods:

  • A comprehensive literature search was conducted using PubMed/Medline from 1980-2017.
  • Keywords included "asthma" or "bronchospasm" and "cocaine" or "freebase" or "crack".
  • English and French articles were selected, with abstracts undergoing dual reading.

Main Results:

  • Cocaine use can trigger asthma onset and acute exacerbations, with higher ICU admission and ventilation rates in users.
  • Case reports showed acute respiratory failure in 45.4% of patients, with a high recovery rate.
  • Asthma prevalence is higher in cocaine users, and vice versa, with lower treatment adherence in cocaine users.

Conclusions:

  • Cocaine use is a potential cause of asthma onset and severe exacerbations, potentially leading to fatal outcomes.
  • Clinicians should systematically evaluate cocaine use in patients with asthma exacerbations.
  • Assisting cocaine users in cessation is crucial for managing their respiratory health.