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Updated: Jan 23, 2026
10:42
Ex Vivo Expansion of Hematopoietic Stem Cells from Human Umbilical Cord Blood-derived CD34+ Cells Using Valproic Acid
Published on: April 11, 2019
10.5K
Valproic Acid-Induced Coagulopathy.
Riten Kumar1, Jorge Vidaurre2, Satyanarayana Gedela2
1Division of Pediatric Hematology/Oncology, Nationwide Children's Hospital, Columbus, Ohio; Department of Pediatrics, The Ohio State University, Columbus, Ohio.
Pediatric Neurology
|June 16, 2019
Summary
Valproic acid can cause thrombocytopenia and other bleeding risks. Physicians should consider hemostatic evaluation for patients on valproic acid undergoing surgery.
Area of Science:
- Hematology
- Pharmacology
- Surgical Complications
Background:
- Valproic acid is a common antiseizure medication.
- Hematologic abnormalities are reported with valproic acid use.
- These risks are relevant in the perioperative setting.
Purpose of the Study:
- Analyze the prevalence of coagulopathy and hemorrhage in patients on valproic acid.
- Investigate the possible etiology of these bleeding complications.
Main Methods:
- Literature search using terms: VPA, coagulopathy, surgery.
- Review of published data from case reports to large case series.
Main Results:
- Thrombocytopenia is the most frequent laboratory abnormality.
- Acquired von Willebrand disease, hypofibrinogenemia, and factor XIII deficiency are suggested.
- Perioperative hemorrhage reported in pediatric orthopedic surgery, not adult neurosurgery.
Conclusions:
- Valproic acid use is linked to thrombocytopenia and coagulation abnormalities.
- Further trials are needed to confirm the association with clinically significant coagulopathy.
- Physicians must be aware of bleeding risks; consider hemostatic evaluation for surgical patients.
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