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Consider the gas molecules in a cylinder. They move in a random motion as they collide with each other and change speed and direction. The average of all the path lengths between collisions is known as the "mean free path."
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Evaluating Leaf Responses to Microbial Secondary Metabolites Using A High-Throughput Format
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The path toward using microbial metabolites as therapies.

Hélène C Descamps1, Beatrice Herrmann1, Daphne Wiredu1

  • 1Microbiology Department, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Ebiomedicine
|June 16, 2019
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Summary

Microbiome-associated metabolites influence human health and disease. These natural compounds show promise as targeted therapies, but clinical translation faces challenges.

Keywords:
DiseaseMetabolitesMicrobiomePost-bioticsTherapies

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Area of Science:

  • Microbiome research
  • Metabolomics
  • Human physiology

Background:

  • Commensal microbiome metabolites are key mediators of physiological effects.
  • Microbiome endocrine activity links to complex diseases, making metabolites therapeutic targets.
  • Metabolites possess properties suitable for intervention: natural occurrence, pleiotropy, ease of administration, and bioavailability.

Purpose of the Study:

  • To provide an overview of recently discovered physiological effects of microbiome-associated small molecules.
  • To highlight potential metabolite-based therapies.
  • To identify challenges in clinical translation of microbial metabolites.

Main Methods:

  • Literature review of microbiome-associated metabolites.
  • Analysis of physiological effects and therapeutic potential.
  • Discussion of challenges for clinical trials.

Main Results:

  • Several microbiome-associated small molecules demonstrate significant physiological effects.
  • These molecules represent potential candidates for novel metabolite-based therapies.
  • The field is advancing with new discoveries in metabolite functions.

Conclusions:

  • Microbiome-modulated metabolites are promising therapeutic agents for human diseases.
  • Overcoming challenges in clinical trials is crucial for successful translation.
  • Further research is needed to fully harness the therapeutic potential of microbial metabolites.