Related Experiment Video

Updated: Jan 23, 2026

Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima
09:13

Sensitive Measurement of Mitophagy by Flow Cytometry Using the pH-dependent Fluorescent Reporter mt-Keima

Published on: August 12, 2018

15.6K

Fatal Vitamin K-Dependent Coagulopathy Associated with Cefoperazone/Sulbactam: A Case Report

Huan-Rong Hu1

  • 1Medical Laboratory, Jiangxi Provincial People's Hospital Affiliated Hospital of Nanchang University, 92 Patriotic Road, Nanchang, 330006, Jiangxi, China. m18310191679@163.com.

Drug Safety - Case Reports
|June 16, 2019
PubMed

Insights

A patient experienced a fatal hemorrhage potentially linked to cefoperazone/sulbactam (CPZ/SAM) treatment, indicating a risk of vitamin K-dependent coagulopathy. Caution is advised when prescribing CPZ/SAM to patients with bleeding risks.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Hematology

Background:

  • Cefoperazone/sulbactam (CPZ/SAM) is a combined antimicrobial formulation.
  • Vitamin K-dependent coagulopathy is a potential adverse effect of certain antibiotics.

Purpose of the Study:

  • To report a suspected fatal adverse reaction of vitamin K-dependent coagulopathy associated with CPZ/SAM.
  • To highlight the potential risk of CPZ-induced hemorrhage.

Main Methods:

  • Case report of a patient treated with intravenous CPZ/SAM for acute cerebral infarction and pulmonary infection.
  • Naranjo assessment score used to evaluate the causality of the adverse reaction.

Main Results:

  • The patient developed a fatal hemorrhage after CPZ/SAM administration.
  • The Naranjo score of 5 suggests a potential association between CPZ/SAM and the coagulation disorder.

Conclusions:

  • CPZ/SAM may be associated with vitamin K-dependent coagulopathy and hemorrhage.
  • Avoidance of cephalosporins, including CPZ/SAM, is recommended in high-risk bleeding patients unless clinically essential.

More Related Videos

Author Spotlight: Optimizing Antibody-Based Cancer Treatments via Antibody-Dependent, Cell-Mediated Cytotoxicity Assay05:21

Author Spotlight: Optimizing Antibody-Based Cancer Treatments via Antibody-Dependent, Cell-Mediated Cytotoxicity Assay

Published on: September 13, 2024

855
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R2029106:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

13.1K

Related Concept Videos

Vitamins01:30

Vitamins

Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.3K
Mineral, Vitamin and Water Absorption01:27

Mineral, Vitamin and Water Absorption

Electrolytes are essential minerals and ions primarily obtained from the diet and absorbed through the gastrointestinal tract. Most electrolytes are absorbed in the small intestine. While the absorption of iron and calcium primarily occurs in the duodenum, calcium is also absorbed in the jejunum and ileum. In these regions, passive diffusion contributes to its absorption alongside active transport mechanisms in the duodenum. These ions can exit the enterocytes through specialized active...
1.5K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.6K
Data Reporting and Recording01:24

Data Reporting and Recording

Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.4K
Frequency-dependent Selection01:21

Frequency-dependent Selection

When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
23.2K
Types of Reports I: Hands-off Report01:25

Types of Reports I: Hands-off Report

A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:
1.5K