Real-Time and Online Monitoring of Glucose Contents by Using Molecular Imprinted Polymer-Based IDEs Sensor.

Area of Science:

• Materials Science
• Analytical Chemistry
• Sensor Technology

Background:

• Development of accurate and reliable glucose monitoring tools is crucial for managing diabetes and related health conditions.
• Existing glucose sensors often face challenges with sensitivity, selectivity, stability, and reusability.
• Artificial receptors offer a promising alternative for creating advanced sensing platforms.

Purpose of the Study:

• To develop a highly sensitive, selective, reversible, and reusable glucose sensor.
• To utilize molecularly imprinted polymer (MIP)-based artificial receptors integrated with an interdigital transducer (IDT).
• To evaluate the sensor's performance characteristics, including detection limits, selectivity, and long-term stability.

Main Methods:

• MIP receptors synthesized using bulk imprinting with styrene, ethylene glycol dimethacrylate (EGDMA), and AIBN.
• Sensor fabrication by immobilizing MIP receptors onto an interdigital transducer.
• Characterization of receptor topography using scanning electron microscopy (SEM).
• Performance evaluation including limit of detection (LOD), limit of quantification (LOQ), selectivity, and regeneration tests.

Main Results:

• The fabricated sensor exhibited a concentration-dependent, linear, and reversible response to glucose.
• Achieved a low limit of detection (LOD) of 30 ppb and an upper limit of detection of approximately 500 ppm.
• Demonstrated high selectivity for glucose in the presence of competing substances.
• Regeneration tests showed less than 2% error over one year under ambient conditions.

Conclusions:

• The developed MIP-based glucose sensor offers excellent sensitivity, selectivity, and reusability.
• The sensor's robust performance and stability suggest significant potential for practical applications.
• Potential applications include medical diagnostics, food analysis, and the pharmaceutical industry.