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Obstetric cholestasis. A 14 year review.
American Journal of Obstetrics and Gynecology
|February 1, 1979
Summary
Obstetric cholestasis, a liver condition during pregnancy, is linked to higher risks of premature labor, low-birth-weight infants, and postpartum hemorrhage. This review highlights key adverse perinatal outcomes associated with this condition.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Hepatology
Background:
- Obstetric cholestasis is a pregnancy-specific liver disorder.
- It is characterized by elevated bile acids and itching during pregnancy.
- Understanding its impact on perinatal outcomes is crucial for clinical management.
Purpose of the Study:
- To determine the incidence of obstetric cholestasis.
- To compare perinatal outcomes in women with obstetric cholestasis versus controls.
- To identify specific adverse outcomes associated with this condition.
Main Methods:
- Retrospective review of 42 cases over 14 years at the Women's Centre, Winnipeg.
- Comparison of perinatal outcomes with a control group.
- Analysis of incidence, labor complications, and infant birth weights.
Main Results:
- An incidence of one in 1,293 deliveries was observed.
- Significantly higher rates of premature labor were found.
- Increased incidence of low-birth-weight babies and postpartum hemorrhage noted.
Conclusions:
- Obstetric cholestasis is associated with adverse perinatal outcomes.
- Premature labor, low birth weight, and postpartum hemorrhage are key risks.
- No significant association with intrapartum fetal distress or intrauterine growth retardation was found.