Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.9K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.9K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.0K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.0K
Adult Stem Cells01:33

Adult Stem Cells

33.4K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.4K
Embryonic Stem Cells00:58

Embryonic Stem Cells

32.1K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.1K
Embryonic Stem Cells00:57

Embryonic Stem Cells

4.8K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
4.8K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

27.3K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
27.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of occlusal contact errors of 6 chairside CAD/CAM crowns: a self-controlled clinical study.

Clinical oral investigations·2022
Same author

Uncovering the emergence of HSCs in the human fetal bone marrow by single-cell RNA-seq analysis.

Cell stem cell·2022
Same author

Intracardiac echocardiography is a safe and effective alternative to transesophageal echocardiography for left atrial appendage thrombus evaluation at the time of atrial fibrillation ablation: The ICE-TEE study.

Pacing and clinical electrophysiology : PACE·2022
Same author

Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2.

Nature communications·2022
Same author

Recent developments in anammox-based membrane bioreactors: A review.

The Science of the total environment·2022
Same author

Octenyl Succinic Anhydride-Modified Starch Attenuates Body Weight Gain and Changes Intestinal Environment of High-Fat Diet-Fed Mice.

Foods (Basel, Switzerland)·2022

Related Experiment Video

Updated: Jan 23, 2026

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

14.0K

New paradigms on hematopoietic stem cell differentiation.

Hui Cheng1,2,3,4, Zhaofeng Zheng5,6,7, Tao Cheng8,9,10,11

  • 1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China. chenghui@ihcams.ac.cn.

Protein & Cell
|June 16, 2019
PubMed
Summary

The classical hematopoietic stem cell (HSC) hierarchy is challenged by new evidence. Research reveals heterogeneity within HSCs and progenitor populations, revising our understanding of blood cell development.

Keywords:
differentiationhematopoietic stem cellheterogeneityhierarchy

More Related Videos

Isolation and Transplantation of Hematopoietic Stem Cells HSCs
20:38

Isolation and Transplantation of Hematopoietic Stem Cells HSCs

Published on: February 25, 2007

24.2K
Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

11.7K

Related Experiment Videos

Last Updated: Jan 23, 2026

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
22:06

Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

Published on: February 25, 2007

14.0K
Isolation and Transplantation of Hematopoietic Stem Cells HSCs
20:38

Isolation and Transplantation of Hematopoietic Stem Cells HSCs

Published on: February 25, 2007

24.2K
Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells
14:37

Directed Differentiation of Primitive and Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

Published on: November 1, 2017

11.7K

Area of Science:

  • Hematology
  • Developmental Biology
  • Stem Cell Biology

Background:

  • Hematopoiesis, the process of blood cell formation, has long been modeled by a strict hierarchy with hematopoietic stem cells (HSCs) at the apex.
  • The classical model posits that HSCs self-renew and sequentially differentiate into all blood lineages.

Purpose of the Study:

  • To review recent evidence challenging the classical model of hematopoiesis.
  • To discuss the heterogeneity observed within HSC and progenitor populations.
  • To explore revised hierarchical models of blood cell development.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of data from single-cell technologies.
  • Examination of studies primarily in mouse models.

Main Results:

  • Evidence suggests significant heterogeneity within HSC and progenitor populations.
  • Novel approaches and technologies are revising traditional hierarchical models of hematopoiesis.
  • The developmental roadmap of blood cell formation is more complex than previously understood.

Conclusions:

  • The classical dogma of hematopoiesis requires revision.
  • Understanding HSC heterogeneity is crucial for a comprehensive view of blood development.
  • Advances in technology are continually refining our knowledge of hematopoietic differentiation.