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Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
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Published on: February 25, 2007

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New paradigms on hematopoietic stem cell differentiation

Hui Cheng1,2,3,4, Zhaofeng Zheng5,6,7, Tao Cheng8,9,10,11

  • 1State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China. chenghui@ihcams.ac.cn.

Protein & Cell
|June 16, 2019
PubMed

Ever since hematopoietic stem cells (HSCs) were first identified half a century ago, their differentiation roadmap has been extensively studied. The classical model of hematopoiesis has long held as a dogma that HSCs reside at the top of a hierarchy in which HSCs possess self-renewal capacity and can progressively give rise to all blood lineage cells. However, over the past several years, with advances in single cell technologies, this developmental scheme has been challenged. In this review, we discuss the evidence supporting heterogeneity within HSC and progenitor populations as well as the hierarchical models revised by novel approaches mainly in mouse system. These evolving views provide further understanding of hematopoiesis and highlight the complexity of hematopoietic differentiation.

Keywords:
differentiationhematopoietic stem cellheterogeneityhierarchy

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