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Updated: Jan 23, 2026
12:03
In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis
Published on: December 9, 2016
12.9K
Hypoxia Mediates Tumor Malignancy and Therapy Resistance
Weibo Luo1,2, Yingfei Wang3,4
1Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA. Weibo.Luo@UTSouthwestern.edu.
Advances in Experimental Medicine and Biology
|June 16, 2019
Summary
Hypoxia, a key feature of tumors, fuels cancer growth and resistance to therapy. Hypoxia-inducible factor (HIF) drives these harmful processes, making it a critical target for cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Hypoxia is a prevalent condition in solid tumors.
- Tumor hypoxia promotes malignant phenotypes and therapeutic resistance.
- Hypoxia-inducible factor (HIF) is a central regulator of cellular responses to low oxygen.
Purpose of the Study:
- To review the causes and detection methods of intratumoral hypoxia.
- To elucidate the oncogenic role of HIF in tumorigenesis.
- To examine HIF's contribution to chemo- and radio-therapy resistance.
Main Methods:
- Literature review of intratumoral hypoxia.
- Analysis of HIF's regulatory functions in cancer.
- Synthesis of data on HIF's impact on therapy outcomes.
Main Results:
- Intratumoral hypoxia arises from various factors and can be detected using specific methods.
- HIF orchestrates critical pathological processes including angiogenesis, metabolic reprogramming, and immune evasion.
- HIF plays a significant role in promoting tumor growth and resistance to chemotherapy and radiotherapy.
Conclusions:
- HIF is a crucial mediator of hypoxia-driven oncogenesis and treatment failure.
- Understanding HIF's functions is vital for developing novel cancer therapies.
- Targeting HIF pathways may overcome therapeutic resistance in hypoxic tumors.
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