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Laser Microdissection-Based Protocol for the LC-MS/MS Analysis of the Proteomic Profile of Neuromelanin Granules
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Transcriptomic and proteomic profiling revealed global changes in Streptococcus thermophilus during pH-controlled

Yali Qiao1, Cong Leng1, Gefei Liu1

  • 1Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin, 150030, Heilongjiang, P. R. China.

Journal of Microbiology (Seoul, Korea)
|June 16, 2019
PubMed
Summary

This study reveals significant gene and protein expression changes in Streptococcus thermophilus during growth, particularly in the late-lag phase. These findings offer insights for optimizing bacterial cultivation and bioprocesses.

Keywords:
Streptococcus thermophilusglobal changesproteomictranscriptomic

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Biotechnology

Background:

  • Optimizing Streptococcus thermophilus growth is crucial for industrial applications.
  • Understanding molecular mechanisms during bacterial growth is essential for bioprocess development.

Purpose of the Study:

  • To investigate global molecular changes during Streptococcus thermophilus growth using transcriptomics and proteomics.
  • To identify key physiological processes affected during different growth phases.

Main Methods:

  • Combined transcriptomics and proteomics analyses.
  • Monitoring gene and protein expression profiles over time during S. thermophilus cultivation.

Main Results:

  • Significant changes in the expression of 1396 genes and 876 proteins were observed.
  • Late-lag phase showed the most dynamic changes, involving heterofermentation, glycolysis, and stress responses.
  • Identified key molecular pathways influencing bacterial growth and biomass production.

Conclusions:

  • The study provides a comprehensive molecular understanding of S. thermophilus growth dynamics.
  • Results can guide the rational design of cultivation media for high-cell-density cultures.
  • Findings support the optimization of bioprocesses for enhanced S. thermophilus biomass yield.