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The roles of Orai and Stim in bone health and disease
Lisa J Robinson1, Harry C Blair2, John B Barnett3
1Department of Pathology, Anatomy, and Laboratory Medicine, West Virginia University School of Medicine, Morgantown WV 26505, United States; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown WV 26505, United States.
Abstract:
Orai and Stim proteins are the mediators of calcium release-activated calcium signaling and are important in the regulation of bone homeostasis and disease. This includes separate regulatory systems controlling mesenchymal stem cell differentiation to form osteoblasts, which make bone, and differentiation and regulation of osteoclasts, which resorb bone. These systems will be described separately, and their integration and relation to other systems, including Orai and Stim in teeth, will be briefly discussed at the end of this review.
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