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Melatonin improves the structure and function of autografted mice ovaries through reducing inflammation: A

Maryam Noori Hassanvand1, Malek Soleimani Mehranjani1, Elham Shojafar1

  • 1Department of Biology, Faculty of Science, Arak University, Arak 381-5688138, Iran.

International Immunopharmacology
|June 16, 2019
PubMed

Insights

Melatonin treatment improved the structure and function of grafted mouse ovaries. It reduced apoptosis and inflammation while enhancing ovarian volume and follicle count.

Area of Science:

  • Reproductive Biology
  • Endocrinology
  • Transplantation Science

Background:

  • Ovarian autograft transplantation is crucial for fertility preservation.
  • Grafted ovaries face challenges like oxidative stress, inflammation, and apoptosis.
  • Melatonin is known for its antioxidant, anti-inflammatory, and anti-apoptotic properties.

Purpose of the Study:

  • To investigate the protective effects of melatonin on mouse ovarian structure and function after autograft transplantation.
  • To evaluate melatonin's impact on ovarian tissue integrity, follicle survival, and hormonal balance.

Main Methods:

  • NMRI mice underwent ovarian autograft transplantation.
  • Groups included control, autografted + saline, and autografted + melatonin (20 mg/kg/day).
  • Ovarian structure, follicle apoptosis, hormone levels (progesterone, estradiol), inflammation markers (IL-6, TNF-α), oxidative stress (MDA), and total antioxidant capacity (TAC) were assessed.

Main Results:

  • Autografted ovaries treated with saline showed decreased ovarian volume, follicle count, progesterone, estradiol, and TAC, alongside increased IL-6, TNF-α, MDA, and apoptosis.
  • Melatonin treatment significantly improved ovarian volume, follicle count, progesterone, estradiol, and TAC compared to the saline group.
  • Melatonin also significantly reduced IL-6, TNF-α, MDA, and apoptosis rates in grafted ovaries.

Conclusions:

  • Melatonin administration effectively mitigates the detrimental effects of oxidative stress and inflammation following ovarian autograft transplantation.
  • Melatonin treatment preserves ovarian structure and function, making it a promising therapeutic agent for improving outcomes in ovarian transplantation.
  • The observed improvements suggest melatonin's potential to enhance the viability and success rate of ovarian autografts.
Keywords:
AutotransplantationIschemia/reperfusionMelatoninMiceOvary

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