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Multifunctional hand-held sensor using electronic components embedded in smartphones for quick PCR screening.

Yoo Min Park1, Chi Hyun Kim1, Seok Jae Lee1

  • 1Nano-bio Application Team, National NanoFab Center (NNFC), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.

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Summary
This summary is machine-generated.

This study presents a novel smartphone-based device for rapid pathogen detection. The portable biosensor uses magnetic particles and smartphone optics to identify bacterial DNA amplicons, enabling quick point-of-care testing.

Keywords:
PCR screeningPathogen optical biosensorPoint-of-care testing (POCT)Smartphone-based biosensing platform

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Area of Science:

  • Biotechnology
  • Biosensing Technology
  • Medical Diagnostics

Background:

  • Current pathogen detection methods can be time-consuming and require specialized equipment.
  • There is a need for rapid, portable, and cost-effective diagnostic tools for point-of-care applications.

Purpose of the Study:

  • To develop a novel, handheld pathogen-detection device utilizing smartphone technology.
  • To integrate functionalized magnetic particles (MPs) and sepharose for affinity chromatography-based DNA amplicon analysis.
  • To create a smartphone-mountable device for centrifugal separation and optical detection.

Main Methods:

  • Utilized smartphone-embedded electronics with functionalized magnetic particles (MPs) and sepharose for affinity chromatography.
  • Employed avidin-conjugated MPs and succinimide-linked sepharose with biotin-primers for DNA amplicon evaluation.
  • Developed a smartphone-mountable rotor powered by the device's charging port to mimic centrifugal separation.
  • Optically analyzed changes in MP position via smartphone illumination sensor, correlating with DNA amplicon binding.

Main Results:

  • Successfully detected amplified genes from Escherichia coli O157:H7 samples.
  • Achieved detection across a range of 1.0 × 10^1 to 1.0 × 10^6 colony-forming units.
  • Demonstrated rapid, naked-eye detection using the smartphone-based optical device.
  • Observed significant changes in MP position during centrifugation due to DNA amplicon binding.

Conclusions:

  • The developed smartphone-based optical device offers a novel and effective biosensing technique.
  • This technology is suitable for rapid point-of-care testing in both industrial and clinical settings.
  • The device provides a portable, cost-effective solution for pathogen detection.