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Flaviviruses and Kidney Diseases.
1Faculdade de Medicina da Universidade de São Paulo, São Paulo, São Paulo, Brazil.
Advances in Chronic Kidney Disease
|June 17, 2019
Summary
Flaviviruses, often mosquito-borne, are spreading globally and can cause severe multisystem diseases. This review focuses on their impact on kidney health, including acute and chronic kidney syndromes.
Area of Science:
- Virology
- Infectious Diseases
- Nephrology
Background:
- The genus Flavivirus includes over 70 viruses, with a significant increase in global incidence and geographic spread.
- Many flaviviruses are arthropod-borne viruses (arboviruses), transmitted by mosquitoes, causing diseases like dengue, Zika, and West Nile fever.
- While often asymptomatic or mild, flavivirus infections can lead to severe, multi-systemic diseases with high morbidity and mortality.
Purpose of the Study:
- To provide a comprehensive overview of kidney involvement in flavivirus infections.
- To discuss the epidemiology, risk factors, and pathogenesis of flavivirus-associated kidney diseases.
- To review the outcomes of acute and chronic kidney syndromes linked to specific flaviviruses.
Main Methods:
- Literature review of flavivirus infections and kidney pathology.
- Analysis of epidemiological data on flavivirus spread and incidence.
- Synthesis of information on clinical manifestations and outcomes of kidney syndromes.
Main Results:
- Flaviviruses are increasingly detected in kidney tissues and urine.
- Specific flaviviruses like dengue, yellow fever, Zika, and West Nile virus are associated with acute and chronic kidney syndromes.
- Understanding the mechanisms of kidney damage is crucial for managing these infections.
Conclusions:
- Flavivirus infections pose a growing threat, with significant implications for kidney health.
- Further research into flavivirus-induced nephropathies is essential for effective public health strategies.
- Early recognition and management of kidney complications are vital for improving patient outcomes.
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