Related Experiment Video
Updated: Jan 23, 2026
06:51
Techniques to Induce and Quantify Cellular Senescence
Published on: May 1, 2017
34.9K
Cellular senescence in cardiac diseases
Ippei Shimizu1, Tohru Minamino2
1Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Division of Molecular Aging and Cell Biology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Journal of Cardiology
|June 17, 2019
Summary
Cellular senescence, a hallmark of aging, involves irreversible cell cycle arrest. Senolysis, the elimination of these senescent cells, shows promise in reversing aging phenotypes and treating age-related cardiovascular diseases.
Area of Science:
- Gerontology and Cellular Biology
- Cardiovascular Research
Background:
- Cellular senescence, characterized by irreversible proliferation arrest, contributes to aging and age-related diseases.
- Current markers for cellular senescence are often indirect, necessitating improved detection methods.
- Senescent cells accumulate in cardiovascular systems, mediating chronic inflammation and tissue remodeling.
Purpose of the Study:
- To explore the role of cellular senescence in aging and cardiovascular disorders.
- To investigate the potential of senolysis as a therapeutic strategy for age-related conditions.
Main Methods:
- Review of existing literature on cellular senescence and senolytic therapies.
- Analysis of molecular markers and genetic alterations in senescent cells.
- Examination of senolysis's impact on aging phenotypes and pathologies in preclinical models.
Main Results:
- Senescent cells exhibit altered genetic profiles and secrete pro-inflammatory factors.
- Senolysis has demonstrated efficacy in reversing aging phenotypes and ameliorating pathologies in age-related disorders.
- Senolysis has shown promise in reversing aging phenotypes specifically in cardiovascular disorders.
Conclusions:
- Cellular senescence is a key driver of aging and cardiovascular disease progression.
- Senolysis represents a novel therapeutic avenue for combating aging and related pathologies.
- Targeting senescent cells offers a promising strategy for developing new therapies for cardiac diseases.
Related Concept Videos
02:15Replicative Cell Senescence
4.3K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.3K
01:22Cardiac Output II: Effect of Stroke Volume on Cardiac Output
3.2K
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
3.2K
00:57Cellular Differentiation
5.2K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
A zygote is a...
5.2K
01:18Cellular Respiration
1.8K
Cellular respiration is a crucial metabolic process through which cells obtain energy from organic substances, mainly glucose, to produce adenosine triphosphate (ATP). This process includes the oxidation of substrates and the transfer of electrons to a separate electron acceptor, facilitating ATP synthesis through a sequence of biochemical reactions.Glycolysis: The Initial StepGlycolysis is the first stage of cellular respiration, occurring in the cytoplasm of both prokaryotic and eukaryotic...
1.8K
01:19Cardiac Output I:Effect of Heart Rate on Cardiac Output
2.5K
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
2.5K
01:29Cardiac Cycle
12.3K
The cardiac cycle refers to the sequence of events that occur in the heart from the beginning of one heartbeat to the next. It's characterized by alternating periods of contraction (systole) and relaxation (diastole) of the heart muscles.
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...
During the cardiac cycle, blood flow through the heart is regulated entirely by changing pressure gradients. This sequence of events begins with the heart in a state of total relaxation, known as mid-to-late diastole, during which blood passively flows from...
12.3K