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alpha 1-Acid glycoprotein, alpha 1-antitrypsin, and ceruloplasmin in human intestinal helminthiases
The American Journal of Tropical Medicine and Hygiene
|January 1, 1979
Insights
Intestinal helminthiases, particularly ancylostomiasis, in tropical children may trigger an acute phase reaction. This response is potentially amplified by T.A.B.-cholera vaccination, affecting key protein levels.
Area of Science:
- Clinical Medicine
- Tropical Medicine
- Immunology
Background:
- Children from rural tropical regions often experience high burdens of intestinal helminthiases.
- Changes in environment and health interventions can impact immune responses and acute phase protein levels.
Purpose of the Study:
- To investigate the impact of relocating to a temperate climate on acute phase protein levels in children.
- To explore the potential role of intestinal helminthiases and T.A.B.-cholera vaccination in modulating these responses.
Main Methods:
- Longitudinal study tracking alpha 1-acid glycoprotein, alpha 1-antitrypsin, and ceruloplasmin levels.
- Study involved 150 children migrating from rural tropics to a temperate zone.
- Analysis considered the presence of intestinal helminthiases and vaccination status.
Main Results:
- Observed alterations in acute phase protein levels in children after relocation.
- Postulated that intestinal helminthiases, specifically ancylostomiasis, induce an acute phase reaction.
- Hypothesized that T.A.B.-cholera vaccine enhances this reaction.
Conclusions:
- Intestinal helminthiases may contribute to an acute phase response in children.
- Vaccination with T.A.B.-cholera may potentiate this inflammatory reaction.
- Further research is needed to confirm the interplay between helminths, vaccination, and acute phase proteins.
Abstract:
alpha 1-acid glycoprotein, alpha 1-antitrypsin, and ceruloplasmin levels were followed in 150 children from the rural tropics after arrival in the temperate zone. It is postulated that multiple intestinal helminthiases, especially ancylostomiasis, cause an acute phase type of reaction which is enhanced by immunization with T.A.B.-cholera vaccine.