Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Plant Hormones01:56

Plant Hormones

27.4K
Plant hormones—or phytohormones—are chemical molecules that modulate one or more physiological processes of a plant. In animals, hormones are often produced in specific glands and circulated via the circulatory system. However, plants lack hormone-producing glands.
27.4K
Cancer Therapies02:49

Cancer Therapies

9.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.9K
Types of Hormones02:13

Types of Hormones

83.2K
Hormones can be classified into three main types based on their chemical structures: steroids, peptides, and amines. Their actions are mediated by the specific receptors they bind to on target cells.
83.2K
Reinforcement Schedules01:24

Reinforcement Schedules

479
Positive reinforcement is a powerful method for teaching new behaviors to both animals and humans. B.F. Skinner demonstrated this with his experiments using rats in a Skinner box. When a rat pressed a lever, it received a food pellet. This immediate reward encouraged the rat to repeat the behavior. This method, where a reward follows every instance of the behavior, is known as continuous reinforcement. It is highly effective for establishing new behaviors quickly.
Once a behavior is learned,...
479
Hormonal Regulation01:33

Hormonal Regulation

35.8K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
35.8K
Hormonal Regulation01:40

Hormonal Regulation

47.9K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
47.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative Aortic Arch Calcification Is Associated with Non-ipsilateral Ischemic Lesions after Transfemoral Carotid Artery Stenting.

Neurologia medico-chirurgica·2026
Same author

Recurrence plot reconstruction reveals chromosomal reorganization before territory formation.

NAR genomics and bioinformatics·2026
Same author

Small sample learning classifies Parkinson's disease patients based on their walking behavior.

Chaos (Woodbury, N.Y.)·2025
Same author

Ischemic Lesions in Diffusion-Weighted Imaging after Carotid Artery Stenting: Correlation with Access Route.

Cerebrovascular diseases extra·2025
Same author

Abundant fluids in southern Kumano Basin linked to fluid source and slow earthquakes at the plate boundary in the Nankai Trough.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Topography of the subducting basement throughout the entire Nankai Trough.

Scientific reports·2025

Related Experiment Video

Updated: Jan 23, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.8K

Practically scheduling hormone therapy for prostate cancer using a mathematical model.

Ayako Nakanishi1, Yoshito Hirata2

  • 1Graduate School of Information Science and Technology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.

Journal of Theoretical Biology
|June 17, 2019
PubMed
Summary

This study introduces a "sparse search" method to optimize intermittent androgen suppression (IAS) schedules for prostate cancer patients. The sparse search effectively delays cancer relapse with manageable computational costs, offering a promising alternative to existing methods.

Keywords:
Intermittent androgen suppression (IAS)Mathematical medicineMathematical modelModel predictive control (MPC)

More Related Videos

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.4K
Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
07:01

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

15.0K

Related Experiment Videos

Last Updated: Jan 23, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.8K
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
06:24

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies

Published on: January 10, 2025

1.4K
Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
07:01

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Published on: August 29, 2016

15.0K

Area of Science:

  • Oncology
  • Mathematical Modeling
  • Computational Biology

Background:

  • Hormone therapy is a key treatment for prostate cancer.
  • Intermittent androgen suppression (IAS) involves repeated cycles of stopping and resuming hormone therapy.
  • Patient responses to IAS vary, with some experiencing cancer relapse.

Purpose of the Study:

  • To compare methods for determining optimal IAS treatment schedules.
  • To delay cancer relapse in patients undergoing IAS.
  • To evaluate the efficacy of a novel
  • Main_Methods
  • sparse search
  • method for scheduling IAS using a mathematical model of prostate cancer.
  • The study compared the
  • sparse search
  • method against exhaustive search and model predictive control (MPC).
  • Mathematical modeling was employed to simulate and analyze treatment outcomes.

Main Methods:

  • The study utilized an existing mathematical model of prostate cancer.
  • A novel
  • sparse search
  • method was developed to determine on- and off-treatment ratios for IAS cycles.
  • Performance was compared against exhaustive search and model predictive control (MPC).

Main Results:

  • The
  • sparse search
  • method successfully identified effective IAS treatment schedules.
  • This approach demonstrated the ability to delay cancer relapse.
  • Computational costs for the sparse search were found to be reasonable compared to exhaustive methods.

Conclusions:

  • The
  • sparse search
  • method is a viable and efficient strategy for optimizing intermittent androgen suppression schedules in prostate cancer.
  • Model predictive control (MPC) shows promise due to computational efficiency and model expandability, despite not always finding optimal schedules in this study.
  • Further investigation into MPC for IAS scheduling is warranted.