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Cytotoxic glycosides from the roots of Weigela x "Bristol Ruby"
Duc Hung Nguyen1, Anne-Claire Mitaine-Offer2, Sveva Maroso3
1PEPITE EA 4267, Laboratoire de Pharmacognosie, UFR des Sciences de Santé, Université de Bourgogne Franche-Comté, BP 87900, 21079 Dijon, Cedex, France; Department of Biology, Thainguyen University of Education, Thainguyen University, 24000 Thainguyen, Viet Nam; Department of Pharmaceutical Technology, PAM UMR A 02.102, PCAV team, Université de Bourgogne Franche-Comté, Dijon, France.
Abstract:
Seven oleanane-type glycosides were extracted and isolated by various chromatographic methods from the roots of Weigela x "Bristol Ruby" (1-7), six previously undescribed (1-6) and a known one (7). Their structures were assigned by spectroscopic analysis mainly 2D NMR and mass spectrometry (ESIMS). Selected triterpenoid glycosides (1-3, 6, 7) displayed a good cytotoxic activity against a mouse colon cancer cell line CT26.