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Updated: Jan 23, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
10:49

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

18.6K

Tyrosine kinase inhibitors and immune checkpoint inhibitors-induced thyroid disorders

Arnaud Jannin1, Nicolas Penel2, Miriam Ladsous1

  • 1Department of Endocrinology and Metabolism, CHU Lille, 59037 Lille, France.

Critical Reviews in Oncology/Hematology
|June 17, 2019
PubMed

Insights

New anticancer drugs, tyrosine kinase inhibitors (TKI) and immune checkpoint inhibitors (ICPIs), can cause thyroid dysfunction. This review assesses their frequency, mechanisms, impact, and management, highlighting the need for thyroid monitoring.

Area of Science:

  • Oncology
  • Endocrinology
  • Pharmacology

Background:

  • Tyrosine kinase inhibitors (TKI) and immune checkpoint inhibitors (ICPIs) are novel anticancer therapies.
  • While often less toxic than chemotherapy, they can induce significant side effects, including thyroid dysfunction.

Purpose of the Study:

  • To review and assess thyroid dysfunctions caused by TKIs and ICPIs.
  • To define the frequency, mechanisms, clinical-biological impact, and management of these toxicities.

Main Methods:

  • Literature assessment of thyroid dysfunctions induced by TKIs and ICPIs.
  • Analysis of reported cases and clinical data.

Main Results:

  • TKIs and ICPIs are associated with various thyroid dysfunctions.
  • Mechanisms of thyroid toxicity are being elucidated.
  • Clinical presentation and biological impact vary.

Conclusions:

  • Thyroid dysfunction is an important adverse effect of TKIs and ICPIs.
  • Monitoring TSH and free T4 is crucial for early detection.
  • Symptomatic treatment for hyperthyroidism and hypothyroidism is necessary.
Keywords:
HypothyroidismImmune checkpoint inhibitorsImmunotherapyThyroiditisThyrotoxicosisToxicityTyrosine kinase inhibitors

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