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Sonothrombolysis with magnetic microbubbles under a rotational magnetic field
Bohua Zhang1, Howuk Kim1, Huaiyu Wu1
1Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh 27695, NC, USA.
Ultrasonics
|June 17, 2019
Summary
Magnetic microbubbles (MMBs) offer enhanced clot lysis compared to traditional methods. A novel rotational magnetic field technique effectively traps and vibrates MMBs at clot sites, significantly improving thrombolysis rates in vitro.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Medical Ultrasound
Background:
- Thrombosis, a critical condition, involves blood clots obstructing blood flow.
- Conventional sonothrombolysis using ultrasound and microbubbles (MBs) shows limited efficacy due to blood flow dispersing MBs.
- A need exists for improved methods to concentrate microbubbles at clot sites for effective lysis.
Purpose of the Study:
- To develop and evaluate a novel sonothrombolysis technique using magnetic microbubbles (MMBs) for enhanced clot lysis.
- To investigate the efficacy of a rotational magnetic field in trapping and activating MMBs at target clot locations.
- To assess the impact of various parameters on thrombolysis rates using this new method.
Main Methods:
- Development of magnetic microbubbles (MMBs) designed for retention against blood flow using an external magnetic field.
- Implementation of a rotational magnetic field to trap and vibrate MMBs at the clot site.
- Utilization of an intravascular forward-looking ultrasound transducer for acoustic activation of MMBs.
- Systematic investigation of factors including blood flow, occlusion status, clot age, ultrasound parameters, and magnetic field parameters.
Main Results:
- The application of magnetic microbubbles significantly improved in vitro blood clot lysis rates.
- The rotational magnetic field successfully trapped and vibrated MMBs at the targeted clot region.
- The method demonstrated effectiveness across various tested conditions, including different blood flow rates and clot ages.
Conclusions:
- The developed method using magnetic microbubbles and a rotational magnetic field represents a significant advancement in sonothrombolysis.
- This technique overcomes the limitations of conventional methods by ensuring MMBs concentration at the clot site.
- The findings suggest a promising new therapeutic strategy for treating thrombotic conditions.
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