Related Experiment Video
Updated: Jan 23, 2026

Tear-Derived Exosomal miR-15a as New Diagnostic Tool for Diabetic Retinopathy
Published on: December 30, 2025
New imaging systems in diabetic retinopathy
Maria Vittoria Cicinelli1, Michele Cavalleri1, Maria Brambati1
1Department of Ophthalmology, Scientific Institute Ospedale San Raffaele, University Vita-Salute, via Olgettina 60, 20132, Milan, Italy.
This review highlights advanced imaging techniques for diabetic retinopathy (DR). Newer noninvasive tools offer comprehensive retinal evaluation for better diagnosis and management of DR.
Area of Science:
- Ophthalmology
- Medical Imaging
- Diabetology
Background:
- Diabetic retinopathy (DR) diagnosis and management rely heavily on imaging.
- Established methods include color photography, fluorescein angiography, and OCT.
- The need for comprehensive peripheral retinal assessment in DR is recognized.
Purpose of the Study:
- To review recent advancements in imaging systems for diabetic retinopathy diagnosis.
- To focus on novel, noninvasive diagnostic tools for DR.
- To illustrate the utility of new imaging modalities in DR screening, grading, treatment, and follow-up.
Main Methods:
- Review of current literature on DR imaging technologies.
- Discussion of established gold-standard imaging techniques.
- Exploration of emerging technologies like fundus autofluorescence, OCT angiography, widefield, and ultra-widefield retinography.
Main Results:
- Color photography, fluorescein angiography, and OCT remain key diagnostic tools.
- Fundus autofluorescence and OCT angiography are gaining clinical validation.
- Widefield and ultra-widefield retinography provide enhanced peripheral retinal evaluation crucial for DR.
Conclusions:
- Recent advancements offer improved diagnostic capabilities for diabetic retinopathy.
- Noninvasive imaging technologies are increasingly important for comprehensive DR assessment.
- New imaging tools aid in the screening, grading, treatment, and follow-up of DR patients.
Related Concept Videos
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Second Order systems II
First Order Systems
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
Second Order systems I
By reinterpreting the system, one can derive the closed-loop transfer function, which...
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Psychoneuroimmunology: Diabetes and Cancer

