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Ischemic stroke associated with anticardiolipin antibodies
S R Levine1, S Kim, M J Deegan
1Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
Stroke
|November 1, 1987
Summary
Anticardiolipin antibodies, a type of antiphospholipid autoantibody, can cause ischemic brain infarction even without lupus anticoagulant activity. This suggests a potential new cause for stroke in patients with these antibodies.
Area of Science:
- Immunology
- Neurology
- Rheumatology
Background:
- Anticardiolipin antibodies are antiphospholipid autoantibodies.
- They are commonly associated with autoimmune diseases like systemic lupus erythematosus.
Observation:
- Three patients experienced ischemic brain infarction.
- Two of these patients did not have systemic lupus erythematosus.
- Lupus anticoagulant activity was not detected in these patients.
Findings:
- Ischemic brain infarction was linked to anticardiolipin antibodies.
- This occurred despite the absence of detectable lupus anticoagulant activity.
- A potential lupus anticoagulant-like thrombotic tendency may be involved.
Implications:
- Anticardiolipin antibodies may represent a newly recognized cause of ischemic stroke.
- This finding broadens the understanding of antiphospholipid syndrome and stroke etiology.
- Further research is warranted to explore the thrombotic mechanisms associated with anticardiolipin antibodies in non-lupus patients.