Related Experiment Video
Updated: Jan 23, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Severe hypersensitivity allergic reaction to filgrastim in a healthy stem cell donor
Divya Doval1, Dharma Choudhary1, Sanjeev K Sharma1
1Department of Hemato-oncology and BMT, BLK Superspeciality Hospital, New Delhi, India.
Introduction:
Granulocyte-colony stimulating factor (G-CSF) has been approved for use for mobilization of hematopoietic progenitor cells from the marrow into the blood for peripheral blood stem cell collection. Commonly reported side effects of G-CSF include deep throbbing bone pain, severe myalgia and leucocytosis.
Case Report:
We describe a case of severe hypersensitivity anaphylactoid reaction after filgrastim administration in a healthy stem cell donor. This haploidentical donor was a 38-year old man with sickle cell trait, donating stem cells for his son, a case of sickle cell disease. On administration of G-CSF (10 µg/kg) he developed features of anaphylaxis.
Management And Outcome:
He was given supportive care with oxygen, IV fluid bolus, anti histaminics and steroids. The donor had complete recovery and underwent successful bone marrow harvest.
Conclusion:
There have been various reports of hypersensitivity anaphylactoid reactions in patients undergoing chemotherapy but those associated with the first dose of G-CSF in healthy stem cell donors have rarely been reported.
More Related Videos
07:01Zebrafish Animal Model for the Study of Allergic Reactions in Response to Tick Saliva Biomolecules
Published on: September 16, 2022
11:59Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies
Published on: September 6, 2017
Related Concept Videos
Allergic Reactions
Allergic Drug Reactions
Hypersensitivities
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Adult Stem Cells
Embryonic Stem Cells
Induced Pluripotent Stem Cells