A flavonoid-based fluorescent test strip for sensitive and selective detection of a gaseous nerve agent simulant

Developing fluorescent sensors with ability of monitoring gaseous nerve agents in a sensitive and selective manner is of great importance due to the extreme toxicity and volatility of organophosphorus nerve agents. Herein we reported a novel oxime-modified flavonoid sensor and carefully investigated its sensing behavior towards nerve agent simulants, diethylchlorophosphate (DCP). In the presence of DCP, a remarkable fluorescence enhancement accompanied with emission color change could be observed by naked eyes in solution. The response time was less than 90 s and LOD value was calculated as 0.78 μmol/L in solution. The sensing mechanism could be ascribed to the specific reaction between halophosphate and hydroxyl group of oxime. Furthermore, sensor strips have been successfully constructed by using PEG as matrix with a simple preparation process, and also achieved the sensitive and selective detection of DCP vapor. These results in this study may provide important references for further design of dye-based sensor strips for detection of nerve agents both in solution and gas phase.