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Hereditary myeloid malignancies.

Hind Rafei¹, Courtney D DiNardo²

¹Division of Cancer Medicine, The University of Texas at MD Anderson Cancer Center, Houston, TX, USA.

Best Practice & Research. Clinical Haematology

|June 18, 2019

Summary

This summary is machine-generated.

Inherited predispositions increase the risk of myeloid leukemia. Recognizing these genetic syndromes is crucial for managing and monitoring patients with myelodysplastic syndromes and acute myeloid leukemia.

Keywords:

Acute myeloid leukemia Bone marrow failure Familial Genetic Germline Hereditary Myelodysplastic syndrome Predisposition

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Area of Science:

Hematology
Oncology
Genetics

Background:

Myelodysplastic syndromes and acute myeloid leukemia predominantly affect the elderly sporadically.
However, inherited genetic predispositions can also lead to these myeloid malignancies.

Purpose of the Study:

To review hereditary conditions predisposing to myeloid leukemia.
To focus on the clinical management and monitoring of these inherited syndromes.

Main Methods:

Literature review of genetic predispositions to myeloid malignancies.
Classification of inherited syndromes into three categories.
Clinical focus on management and monitoring strategies.

Main Results:

Inherited myeloid leukemia arises from familial cancer syndromes (e.g., Li-Fraumeni, CMMRD).
Specific germline mutations (e.g., ANKRD26, CEBPA, DDX41, ETV6, GATA2, RUNX1, SRP72) increase risk.
Pediatric inherited bone marrow failure syndromes (e.g., Fanconi anemia, dyskeratosis congenita) are also implicated.

Conclusions:

Recognition of germline predispositions is essential for patient management.
Effective monitoring and follow-up are critical for individuals with hereditary myeloid leukemia.