Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuron-specific enolase and malignant lymphomas (23 cases).

J Nemeth1, A Galian, J Mikol

  • 1Service Central d'Anatomie et Cytologie Pathologiques, Hôpital Lariboisière, Paris, France.

Virchows Archiv. A, Pathological Anatomy and Histopathology
|January 1, 1987
PubMed
Summary

Polyclonal neuron-specific enolase (NSE) is not a reliable marker for malignant lymphoma (ML). While some ML cases showed NSE positivity, it lacked consistent correlation with cell type, morphology, or phenotype, indicating its inconstant nature.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of women with abnormal cervical cytology: Update of French guidelines after the implementation of HPV screening.

European journal of obstetrics, gynecology, and reproductive biology·2025
Same author

Developmental exposure to an environmentally relevant dose of Bisphenol S impairs postnatal growth and disrupts placental transcriptional profile in female rat.

Reproductive toxicology (Elmsford, N.Y.)·2025
Same author

Joint Disease Activity in Inflammatory Bowel Disease-associated Peripheral Spondyloarthritis Stratifies Therapeutic Response.

Gastro hep advances·2022
Same author

[Genetic diversity and evolution of primate Gammaherpesvirinae].

Virologie (Montrouge, France)·2021
Same author

Annales de dermatologie et de venereologie·2020
Same author

[Multidisciplinary consultation for patients with HPV-related invasive carcinoma or precancerous lesions].

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique·2018

Area of Science:

  • Immunohistochemistry
  • Oncology
  • Cellular Biology

Background:

  • Neuron-specific enolase (NSE) is a biomarker investigated for its potential in diagnosing and characterizing various cancers.
  • Malignant lymphoma (ML) encompasses a heterogeneous group of lymphoid neoplasms with diverse clinical and pathological features.

Purpose of the Study:

  • To investigate the immunoreactivity of polyclonal antiserum to neuron-specific enolase (NSE) in malignant lymphoma (ML).
  • To determine if NSE expression is a specific or consistent marker in different types of ML.

Main Methods:

  • Immunohistochemical analysis of 23 malignant lymphoma cases using polyclonal antiserum to neuron-specific enolase (NSE).
  • Comparison of findings with existing literature on NSE expression in ML.

Related Experiment Videos

Main Results:

  • 11 out of 23 (47.8%) malignant lymphoma cases exhibited detectable NSE positivity (either strong or weak).
  • NSE positivity was observed across various ML subtypes, including B-cell and T-cell lymphomas.
  • No clear correlation was found between NSE reactivity and the morphology or immunophenotype of the lymphoma cells.

Conclusions:

  • Polyclonal neuron-specific enolase (NSE) is not a specific diagnostic marker for malignant lymphoma (ML).
  • NSE expression in ML appears to be inconstant and lacks a predictable association with lymphoma subtype, morphology, or phenotype.