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Related Experiment Video

Updated: Jan 23, 2026

A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton
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Mechanical Function of the Nucleus in Force Generation during Epithelial Morphogenesis.

Arnaud Ambrosini1, Mégane Rayer1, Bruno Monier1

  • 1LBCMCP, Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France.

Developmental Cell
|June 18, 2019
PubMed
Summary

Dying cells in Drosophila leg folding generate apico-basal forces using a dynamic actomyosin tether connecting the cell apex to a basal nucleus. This nucleus, anchored by F-actin, actively participates in mechanical force production during tissue remodeling.

Keywords:
DrosophilaLINCLive imagingTalinactomyosinapoptosisbasal adhesionlinker of nucleoskeleton and cytoskeleton complexmechanical forcesmorphogenesisnucleus

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Area of Science:

  • Cell biology
  • Developmental biology
  • Biophysics

Background:

  • Mechanical forces regulate cell shape and tissue development.
  • Apico-basal forces are crucial for 3D tissue remodeling.
  • The cellular machinery for these forces is not well understood.

Purpose of the Study:

  • Investigate the cellular mechanisms generating apico-basal forces during Drosophila leg folding.
  • Identify the components involved in force production and transmission.

Main Methods:

  • Live imaging of Drosophila leg development.
  • Actomyosin dynamics visualization.
  • Laser ablation experiments.
  • F-actin staining.

Main Results:

  • Dying cells form a dynamic actomyosin contractile tether.
  • This tether connects the apical surface to a basally relocalized nucleus.
  • The nucleus is anchored to basal adhesions via an F-actin network.
  • Laser ablation confirms force transmission to the nucleus and apical surface.

Conclusions:

  • The nucleus actively participates in mechanical force production.
  • The nucleus connects the actomyosin cytoskeleton to basal adhesions.
  • This mechanism is essential for tissue remodeling during development.