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Iron overload and iron chelation therapy in thalassaemia and sickle cell haemoglobinopathies
1Section of Haematology, MRC Clinical Research Centre and Northwick Park Hospital, Harrow, UK.
Acta Haematologica
|January 1, 1987
This paper reviews the factors governing the rate of iron loading and iron toxicity in the thalassaemia syndromes and sickle cell disease. It outlines the main determinants of iron mobilization by the iron-chelating drug, desferrioxamine, together with the effects of this drug in clinical practice.
This paper reviews the factors governing the rate of iron loading and iron toxicity in the thalassaemia syndromes and sickle cell disease. It outlines the main determinants of iron mobilization by the iron-chelating drug, desferrioxamine, together with the effects of this drug in clinical practice.