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[Prognostic Value of CD14+HLA-DRlow/- Myeloid Derived Suppressor Cells in Diffuse Large B Cell Lymphoma]

Chen-Xin Wu1, Ming Qiang2, Ji-Qing Hao3

  • 1Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China,Department of Oncology, The 901th Hospital of the Joint Logistics Support Force of PLA, Hefei 230031, Anhui Province, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi
|June 18, 2019
PubMed

Insights

Myeloid-derived suppressor cells (MDSC) are elevated in diffuse large B cell lymphoma (DLBCL) patients. Higher MDSC levels independently predict poorer overall survival in DLBCL.

Area of Science:

  • Immunology
  • Oncology
  • Hematology

Background:

  • Diffuse large B cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
  • Understanding prognostic factors is crucial for optimizing patient management.
  • The role of the tumor immune microenvironment in DLBCL prognosis requires further elucidation.

Purpose of the Study:

  • To investigate the prognostic significance of myeloid-derived suppressor cells (MDSC) in patients with DLBCL.
  • To determine if MDSC levels correlate with clinical parameters and survival outcomes in DLBCL.

Main Methods:

  • Peripheral blood samples were collected from 52 DLBCL patients and 30 healthy controls.
  • Myeloid-derived suppressor cells (MDSC) were identified using the immune marker CD14+HLA-DRlow/-.
  • Correlation analysis was performed between MDSC levels and clinicopathological data, including staging, LDH, IPI score, and survival.

Main Results:

  • MDSC proportions were significantly increased in newly diagnosed DLBCL patients compared to healthy volunteers (P<0.01).
  • MDSC levels correlated with clinical staging, lactate dehydrogenase (LDH) levels, and International Prognostic Index (IPI) scores in DLBCL patients (P<0.01).
  • Univariate and multivariate analyses identified IPI score and MDSC levels as independent risk factors for overall survival (OS) in DLBCL patients.

Conclusions:

  • Myeloid-derived suppressor cells (MDSC) represent a significant independent prognostic factor for overall survival in DLBCL.
  • MDSC levels can serve as a valuable biomarker for assessing the immune microenvironment and prognosis in DLBCL patients.
  • These findings highlight the potential of targeting MDSC for therapeutic strategies in DLBCL.
Abstract

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