The authors reply

Lucas Bulgarelli¹, Rodrigo Octavio Deliberato, David J Stone+2

• ¹Big Data Analytics Department, Hospital Israelita Albert Einstein, São Paulo, Brazil, and Laboratory for Critical Care Research, Critical Care Department, Hospital Israelita Albert Einstein, São Paulo, Brazil, and MIT Critical Data, Laboratory for Computational Physiology, Harvard-MIT Health Sciences & Technology, MIT, Cambridge, MA MIT Critical Data, Laboratory for Computational Physiology, Harvard-MIT Health Sciences & Technology, MIT, Cambridge, MA, and Departments of Anesthesiology and Neurosurgery, University of Virginia School of Medicine, Charlottesville, VA; MIT Critical Data, Laboratory for Computational Physiology, Harvard-MIT Health Sciences & Technology, MIT, Cambridge, MA, and Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA; MIT Critical Data, Laboratory for Computational Physiology, Harvard-MIT Health Sciences & Technology, MIT, Cambridge, MA.