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A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
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[Bilateral deafness due to the local use of framycetin (author's transl)]

G Renou, G Sénéchal, J M Sterkers

    Annales D'Oto-Laryngologie Et De Chirurgie Cervico Faciale : Bulletin De La Societe D'Oto-Laryngologie Des Hopitaux De Paris
    |October 1, 1978
    PubMed

    Insights

    Framycetin antibiotic ear drops caused severe bilateral cochlear and vestibular damage. Framycetin was detected in inner ear fluid three weeks post-instillation, indicating prolonged toxicity.

    Area of Science:

    • Ototoxicity
    • Pharmacology
    • Neuroscience

    Background:

    • Framycetin is an aminoglycoside antibiotic used for topical ear infections.
    • Local administration of Framycetin is generally considered safe with minimal systemic absorption.
    • Previous literature reports rare instances of Framycetin toxicity.

    Observation:

    • A case of total bilateral cochlear and vestibular destruction is presented.
    • The damage occurred after Framycetin instillation into the middle ear under pressure via a transtympanic drain.
    • This method of administration may increase the risk of ototoxicity.

    Findings:

    • Framycetin was detected in perilymphatic fluid via stapes footplate puncture.
    • Detection occurred three weeks after the initial Framycetin instillation.
    • This confirms the persistence of the drug in the inner ear.

    Implications:

    • Local Framycetin use, especially under pressure, can lead to severe, irreversible inner ear damage.
    • The findings highlight the potential for delayed and prolonged ototoxicity.
    • Clinical vigilance and careful administration techniques are crucial when using Framycetin in the middle ear.

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