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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Related Experiment Video

Updated: Jan 23, 2026

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Correlations between the serum bilirubin level and ulcerative colitis: a case-control study.

Haitao Shi, Yuan Feng, Jiong Jiang

    European Journal of Gastroenterology & Hepatology
    |June 18, 2019
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    Summary

    Lower levels of total bilirubin (TBIL) and indirect bilirubin (IBIL) are linked to ulcerative colitis (UC). IBIL, in particular, shows moderate predictive value for UC, with levels below 6.735 µmol/l indicating potential risk.

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    Area of Science:

    • Gastroenterology
    • Clinical Biochemistry

    Background:

    • Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
    • The role of bilirubin levels in UC pathogenesis is not fully understood.

    Purpose of the Study:

    • To investigate bilirubin levels as a potential protective factor in UC.
    • To assess the predictive value of bilirubin levels for UC diagnosis.

    Main Methods:

    • Compared bilirubin levels in 100 UC patients and 140 healthy controls.
    • Analyzed bilirubin levels across different UC severity subgroups.
    • Correlated bilirubin with erythrocyte sedimentation rate (ESR) and high-sensitivity C-reactive protein (hs-CRP).
    • Utilized receiver operating characteristic (ROC) curve analysis for predictive value.

    Main Results:

    • Mean total bilirubin (TBIL) and indirect bilirubin (IBIL) were lower in UC patients than controls.
    • TBIL and IBIL levels were higher in mild UC compared to moderate/severe UC.
    • TBIL and IBIL demonstrated significant protective effects against UC.
    • Lower bilirubin levels correlated negatively with inflammatory markers (ESR, hs-CRP).
    • ROC analysis indicated moderate predictive value for IBIL (AUC=0.716).

    Conclusions:

    • TBIL and especially IBIL may act as independent protective factors for UC due to antioxidant and anti-inflammatory properties.
    • Low IBIL levels (<6.735 µmol/l) possess moderate predictive value for UC.
    • IBIL levels can serve as a potential biomarker for predicting UC development.