Related Experiment Video
Updated: Jan 23, 2026

Predictive Immune Modeling of Solid Tumors
Published on: February 25, 2020
Thrombocytopenia in solid tumors: Prognostic significance
Majid Ghanavat1, Mina Ebrahimi2, Hassan Rafieemehr3
1Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan.
Abstract:
Solid tumors are a heterogeneous group of malignancies that result from out-of-control proliferation of cells. Thrombocytopenia is a common complication among patients with solid tumors that predispose them to bleeding disorders. The aim of this review article is to investigate the underlying mechanisms of the risk and incidence of thrombocytopenia in solid tumors. It can be argued that thrombocytopenia is a poor prognostic factor in solid tumors that can result from several factors such as polymorphism and mutation in some transcription factors and cytokines involved in megakaryocytic maturation or from the adverse effects of treatment. Therefore, an understanding of the exact mechanism of thrombocytopenia pathogenesis in each stage of solid tumors can help in developing therapeutic strategies to decrease bleeding complications in these malignancies.
Related Concept Videos
Statistical Significance
Cholesterol: Significance and Regulation
Considering cholesterol and...
The Significance of Membrane Transport
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Significance of Center of Mass
Metallic Solids
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
Structures of Solids

