Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecular Models02:00

Molecular Models

43.6K
Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
43.6K
Switching of BJT01:22

Switching of BJT

814
Switching behavior in Bipolar Junction Transistors (BJTs) is a fundamental aspect utilized in various electronic circuits, particularly for digital logic applications like switches and amplifiers. In a typical switching circuit, a BJT alternates between cut-off and saturation modes, corresponding to the "off" and "on" states, respectively, thus behaving like an ideal switch.
Cut-off Mode ("Off" State): In this state, both the emitter-base and collector-base junctions are...
814
Abnormal Proliferation02:23

Abnormal Proliferation

5.1K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K
Structure of Benzene: Molecular Orbital Model01:18

Structure of Benzene: Molecular Orbital Model

12.2K
According to the molecular orbital (MO) model, benzene has a planar structure with a regular hexagon of six sp2 hybridized carbons. As shown in Figure 1, each carbon is bonded to three other atoms with C–C–C and H–C–C bond angles of 120°. The C–H bond length is 109 pm, and the C–C bond length is 139 pm which is midway between the single bond length of sp3 hybridized carbons (154 pm) and sp2 hybridized carbons (133 pm).
12.2K
Molecular Orbital Theory II03:51

Molecular Orbital Theory II

27.0K
Molecular Orbital Energy Diagrams
27.0K
Molecular and Ionic Solids02:54

Molecular and Ionic Solids

20.0K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reforming the cellular, molecular, and genetics course in a graduate biomedical science program: CIPP guided course evaluation.

Pakistan journal of medical sciences·2026
Same author

Peer assessment and feedback for effective lecturing in basic medical sciences-a mixed method study.

BMC medical education·2026
Same author

The intersection of disorders of sex development and cardiovascular diseases.

Biology of sex differences·2026
Same author

Changes in electrical vectors correlated with coronary insufficiency with recent symptoms.

Scientific reports·2025
Same author

Early Cardiac Ischemia-Reperfusion Injury: Interactions of Autophagy with Galectin-3 and Oxidative Stress.

Biomedicines·2024
Same author

Reflections on alma mater: Origin and evolution of Ruhr University Bochum.

Pakistan journal of medical sciences·2024
Same journal

Generation of human chemically induced pluripotent stem cells from UC-MSCs.

Cell regeneration (London, England)·2026
Same journal

Standard: human breast cancer organoids derived from diverse clinical sample sources.

Cell regeneration (London, England)·2026
Same journal

Olfactory epithelium regeneration and homeostasis: cellular and molecular mechanisms and novel methodological advances.

Cell regeneration (London, England)·2026
Same journal

Tollip antagonizes ESCRT-III-mediated plasma membrane repair and cell recovery.

Cell regeneration (London, England)·2026
Same journal

Advances in the application of human amniotic membrane for tissue repair.

Cell regeneration (London, England)·2026
Same journal

Cellular senescence in skeletal muscle regeneration.

Cell regeneration (London, England)·2026
See all related articles

Related Experiment Video

Updated: Jan 23, 2026

Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes
05:06

Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes

Published on: May 5, 2020

14.3K

Molecular switch model for cardiomyocyte proliferation.

Satwat Hashmi1, H R Ahmad1

  • 1Department of Biological and Biomedical Sciences, Aga Khan University, Karachi.

Cell Regeneration (London, England)
|June 18, 2019
PubMed
Summary
This summary is machine-generated.

Adult cardiomyocytes can be induced to divide, offering a new path for heart repair. Understanding how to release their

Keywords:
Cardiomyocyte proliferationCell cycleCyclinsHeart regeneration

More Related Videos

Isolation and Cryopreservation of Neonatal Rat Cardiomyocytes
07:05

Isolation and Cryopreservation of Neonatal Rat Cardiomyocytes

Published on: April 9, 2015

13.2K
An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
09:14

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth

Published on: August 11, 2011

16.3K

Related Experiment Videos

Last Updated: Jan 23, 2026

Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes
05:06

Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes

Published on: May 5, 2020

14.3K
Isolation and Cryopreservation of Neonatal Rat Cardiomyocytes
07:05

Isolation and Cryopreservation of Neonatal Rat Cardiomyocytes

Published on: April 9, 2015

13.2K
An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
09:14

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth

Published on: August 11, 2011

16.3K

Area of Science:

  • Cardiovascular Biology
  • Cell Cycle Regulation
  • Regenerative Medicine

Background:

  • Adult cardiomyocytes are terminally differentiated and typically do not divide.
  • Heart injury leads to scar formation, limiting natural repair mechanisms.
  • Regaining cardiomyocyte proliferative capacity is crucial for myocardial regeneration.

Purpose of the Study:

  • To review the mechanisms controlling adult cardiomyocyte proliferation.
  • To explore the potential of cardiomyocyte cell cycle re-entry for heart repair.
  • To discuss signaling pathways and molecular regulators involved in cardiomyocyte division.

Main Methods:

  • Review of current literature on cardiomyocyte cell cycle control.
  • Analysis of signaling pathways (Notch, Hippo, Wnt, Akt, Jak/Stat) involved in cell cycle checkpoints.
  • Examination of transcription factors, cyclins, CDKs, and inhibitory proteins (p21, p27, p57).

Main Results:

  • The cell cycle of adult cardiomyocytes can be released by modulating cell cycle checkpoints.
  • Specific signaling pathways and transcription factors promote or inhibit cardiomyocyte proliferation.
  • Paracrine factors and extracellular matrix proteins influence cardiomyocyte dedifferentiation and proliferation.

Conclusions:

  • A molecular switch model explains the transition from post-mitotic to dividing cardiomyocytes.
  • Injury-induced signals can activate pathways to promote myocardial regeneration.
  • Targeting cell cycle regulators offers a promising strategy for cardiac repair.