Cobimetinib- and vemurafenib-induced granulomatous dermatitis and erythema induratum: A case report
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Updated: Jan 23, 2026

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
Marco Aj Iafolla1, Jennifer Ramsay2, Judy Wismer3
1Department of Medical Oncology, Juravinski Cancer Centre, McMaster University, Hamilton, ON, Canada.
Abstract:
Metastatic melanoma is an aggressive malignancy. Survival can be increased with the combination of BRAF and MEK inhibition. BRAF inhibitor-induced cutaneous toxicities can be attenuated with MEK inhibition. Here, we describe the first reported case of a patient with metastatic melanoma who developed granulomatous dermatitis and erythema induratum when treated with combination BRAF (vemurafenib) and MEK inhibitor (cobimetinib) therapy and discuss the clinical features and management of dermatologic side-effects secondary to BRAF +/- MEK inhibition.
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