Related Experiment Video

Updated: Jan 23, 2026

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis
04:05

Author Spotlight: Unveiling Prognostic Indicators in Heart Failure - The Role of Phase Angle and Bioelectrical Impedance Analysis

Published on: June 30, 2023

2.8K

Ivabradine in Congestive Heart Failure: Patient Selection and Perspectives

Yasar Sattar1, Elham Neisani Samani2, Fnu Zafrullah3

  • 1Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, USA.

Cureus
|June 18, 2019
PubMed

Insights

Heart failure with reduced ejection fraction (HFrEF) is a major public health concern. Ivabradine shows promise for improving quality of life and survival in HFrEF patients, offering a new therapeutic option.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Heart failure (HF) is a leading cause of mortality globally.
  • Heart failure with reduced ejection fraction (HFrEF) presents significant challenges in patient management and public health.
  • Current treatments aim to improve quality of life, prolong survival, and reduce hospitalizations.

Purpose of the Study:

  • To review current knowledge on ivabradine's role in managing HFrEF.
  • To assess the impact of ivabradine on patient outcomes in HFrEF.
  • To evaluate ivabradine as a potential therapeutic addition for HFrEF.

Main Methods:

  • Literature review of studies on ivabradine in HFrEF.
  • Analysis of clinical trial data regarding ivabradine's efficacy.
  • Assessment of ivabradine's effect on quality of life, survival, and hospitalization rates.

Main Results:

  • Ivabradine is a promising approach for HFrEF management.
  • Potential benefits include improved quality of life and prolonged survival.
  • Ivabradine may be effective alone or in combination with beta-blockers.

Conclusions:

  • Ivabradine represents a novel therapeutic strategy for HFrEF.
  • Further research and wider availability could enhance its clinical utility.
  • Optimizing HFrEF treatment remains a critical goal in cardiovascular medicine.

Keywords:
heart failureheart failure decompensationheart failure with reduced ejection fraction (hfref)heart rateivabradinemortalitynyha functional classrehospitalization

More Related Videos

Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients03:47

Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients

Published on: July 12, 2024

1.1K
Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure04:20

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure

Published on: October 1, 2019

6.2K

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
798
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
3.1K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
737
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
280
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
830
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
232