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Effect of Comprehensive Cerebral Protection Program on Cerebral Oxygen Metabolism and Vascular Endothelial Function

Meihong Zhou1, Zhaojun Huang1

  • 1Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang 330000, P.R. China.

Iranian Journal of Public Health
|June 18, 2019
PubMed

Insights

Comprehensive cerebral protection significantly improved cerebral oxygen metabolism and vascular endothelial function in elderly patients with acute cerebral infarction. This treatment enhanced oxygen delivery and reduced harmful markers, showing significant clinical value.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Geriatrics

Background:

  • Acute cerebral infarction affects elderly patients, impacting cerebral oxygen metabolism and vascular endothelial function.
  • Effective interventions are crucial for managing this condition and improving patient outcomes.

Purpose of the Study:

  • To investigate the impact of comprehensive cerebral protection on cerebral oxygen metabolism and vascular endothelial function in elderly patients with acute cerebral infarction.

Main Methods:

  • 168 elderly patients with acute cerebral infarction were divided into a control group (conventional treatment) and an observation group (comprehensive cerebral protection).
  • Cerebral oxygen metabolism, hemorheology, and vascular endothelial function were assessed before and after treatment.

Main Results:

  • The observation group showed significantly greater improvements in cerebral oxygen metabolism markers (e.g., Da-vO2, OEF, SpO2, NO) compared to the control group.
  • Comprehensive cerebral protection led to significant reductions in jugular venous oxygen saturation (SjvO2), brain oxygen uptake rate (ERO2), endothelin (ET), intracranial pressure (ICP), and blood viscosity parameters in the observation group.
  • Vascular endothelial function markers and hemorheological parameters were favorably altered in the observation group, with statistically significant differences (P<0.05).

Conclusions:

  • Comprehensive cerebral protection is an effective strategy for improving cerebral oxygen metabolism and vascular endothelial function in elderly patients with acute cerebral infarction.
  • The treatment positively influences blood rheology, indicating significant clinical value for managing acute cerebral infarction in this population.
Abstract

Keywords:
Acute cerebral infarctionCerebral oxygen metabolismComprehensive cerebral protectionEndothelial functionSenile

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