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Updated: Jan 23, 2026

Isolation and Decellularization of a Whole Porcine Pancreas
Published on: October 10, 2018
Inflammatory Reaction to Decellularized Porcine-Derived Xenograft for Lower Eyelid Retraction
Norberto Mancera1, Alexander Schneider1, Curtis E Margo1,2
1Department of Ophthalmology.
Abstract:
A 54-year-old woman underwent uncomplicated bilateral lower eyelid surgery for eyelid retraction using porcine decellularized membrane graft (TarSys). Left lower eyelid pain began several months after surgery and persisted until the graft was removed 15 months after implantation. The opposite eyelid graft caused no symptoms. Histologically, the lesion consisted of acellular collagen surrounded by florid granulomatous inflammation. Although the inflammatory reaction suggested a cell-mediated immune response, this pathway of injury is difficult to reconcile given the asymptomatic opposite eyelid. The literature reflects limited experience with porcine decellularized membranes of the eyelid. Complications and long-term tolerance remain to be determined.
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