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Related Concept Videos

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A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma DIPG
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Drug concentrations in post-mortem specimens.

Raimo A Ketola1, Pirkko Kriikku1

  • 1Forensic Toxicology Unit, National Institute for Health and Welfare (THL), Mannerheimintie 166, FI-00270, Helsinki, Finland.

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|June 18, 2019
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Summary
This summary is machine-generated.

This study analyzed drug concentrations in post-mortem samples, finding tissue-to-blood ratios vary by drug. It provides a guide for interpreting toxicological results when femoral blood is unavailable.

Keywords:
drug concentrationforensic toxicologypost-mortemtissue

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Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry

Background:

  • Accurate interpretation of post-mortem drug concentrations is crucial for forensic investigations.
  • Femoral blood is a standard specimen, but its availability can be compromised in post-mortem cases.

Purpose of the Study:

  • To systematically analyze drug concentrations across various post-mortem specimens.
  • To establish reliable ratios of drug concentrations in different tissues relative to femoral blood.
  • To provide a framework for selecting alternative biological specimens for toxicological analysis when femoral blood is absent.

Main Methods:

  • Meta-analysis of 10,993 analytical results from 5,375 post-mortem cases across 388 studies.
  • Inclusion of data from a laboratory's own database (2000-2018).
  • Calculation of drug concentration ratios between various tissues (e.g., vitreous humor, liver, bile) and femoral blood.

Main Results:

  • Significant variation in drug concentration ratios between post-mortem specimens and femoral blood, highly dependent on the specific compound.
  • Vitreous humor, muscle, and other blood (e.g., cardiac blood) showed concentrations similar to femoral blood.
  • Liver and bile generally exhibited the highest drug concentrations.

Conclusions:

  • A ranked order of preferred biological specimens for quantitative toxicological analysis is proposed when femoral blood is unavailable: other blood, muscle, vitreous humor, brain, heart, spleen, kidney, liver, and bile.
  • This data-driven approach aids toxicologists in interpreting drug levels from alternative specimens.
  • The findings enhance the reliability of post-mortem drug analysis in challenging cases.