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Updated: Jan 23, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Optimization of integrated chromatography sequences for purification of biopharmaceuticals
Anton Löfgren1, Mikael Yamanee-Nolin1, Simon Tallvod1
1Department of Chemical Engineering, Lund University, Lund, Sweden.
Abstract:
With continued development of integrated and continuous downstream purification processes, tuning and optimization become increasingly complicated with additional parameters and codependent variables over the sequence. This article offers a novel perspective of nonlinear optimization of integrated sequences with regard to individual column sizes, flow rates, and scheduling. The problem setup itself is a versatile tool to be used in downstream design which is demonstrated in two case studies: a four-column integrated sequence and a continuously loaded twin-capture setup with five columns.
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