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Updated: Jan 23, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
Published on: July 3, 2020
Nonlinear Mixed-Effects Model Development and Simulation Using nlmixr and Related R Open-Source Packages
Matthew Fidler1, Justin J Wilkins2, Richard Hooijmaijers3
1Novartis Pharmaceuticals Corporation, Fort Worth, Texas, USA.
Abstract:
nlmixr is a free and open-source R package for fitting nonlinear pharmacokinetic (PK), pharmacodynamic (PD), joint PK-PD, and quantitative systems pharmacology mixed-effects models. Currently, nlmixr is capable of fitting both traditional compartmental PK models as well as more complex models implemented using ordinary differential equations. We believe that, over time, it will become a capable, credible alternative to commercial software tools, such as NONMEM, Monolix, and Phoenix NLME.
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