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Pediatric-onset psychogenic nonepileptic seizures: A retrospective international multicenter study

Ali A Asadi-Pooya1, Lorna Myers2, Kette Valente3

  • 1Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran; Jefferson Comprehensive Epilepsy Center, Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania, PA, USA.

Seizure
|June 18, 2019
PubMed

Insights

Pediatric-onset psychogenic nonepileptic seizures (PNES) show universal risk factors across cultures, but seizure presentation varies internationally. This cross-cultural study highlights similarities and differences in PNES characteristics globally.

Area of Science:

  • Neurology
  • Psychiatry
  • Cross-cultural studies

Background:

  • Pediatric-onset psychogenic nonepileptic seizures (PNES) are a significant clinical challenge.
  • Understanding cross-cultural variations in PNES is crucial for effective diagnosis and management.

Purpose of the Study:

  • To compare clinical characteristics of pediatric-onset PNES across five countries.
  • To advance the global understanding of pediatric PNES through international collaboration.

Main Methods:

  • Retrospective analysis of consecutive pediatric-onset PNES patients (age ≤ 16 years) from epilepsy monitoring units in Iran, Brazil, USA, Canada, and Venezuela.
  • Data extraction included age, gender, seizure onset, semiology, predisposing factors, and video-EEG.
  • Statistical analysis employed Pearson Chi-Square, one-way ANOVA, and Bonferroni correction.

Main Results:

  • 229 patients were analyzed, with varying representation from each country.
  • Mean age at onset was 12.1 ± 3.2 years; the female-to-male ratio was 1.83:1.
  • Significant international differences in clinical characteristics were observed, yet associated risk factors for PNES were similar across nations.

Conclusions:

  • International cross-cultural studies are vital for understanding PNES.
  • Similarities in risk factors suggest universality in pediatric-onset PNES.
  • Observed differences in seizure semiology may be influenced by cultural factors.
Abstract

Keywords:
Cross-culturalInternationalPediatricPsychogenicSeizure

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