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Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

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Antioxidant activities and molecular docking of 2-thioxobenzo[g]quinazoline derivatives

Rashad Al-Salahi¹, Hanan A A Taie², Ahmed H Bakheit³

¹Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Pharmacological Reports : PR

|June 18, 2019

Abstract

Background:

Oxidative stress and related diseases resulting from the overproduction of free radicals can be counteracted by designing and developing novel antioxidative agents that can protect the human body against the damage caused by free radicals.

Methods:

The present study evaluated the antioxidant activities of 15 derivatives of 2-thioxobenzo[g]quinazoline using three different assays: 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, reducing power capability, and ferric reduction antioxidant power.

Results:

Some benzoquinazolines had good activity and had the capacity to deplete DPPH and free radicals compared to a positive control butylated hydroxyl toluene (BHT). A docking study identified the possible interactions between binding models and the antioxidant activities of the target compounds.

Conclusions:

The active compounds can be used as templates for further development of more potent antioxidative agents.

Keywords:

Antioxidant capacity BHT Benzoquinazolines DPPH Molecular docking Reducing power

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