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Interleukin-6 and Interleukin-10 in mood disorders: A population-based study
Carolina David Wiener1, Fernanda Pedrotti Moreira2, Luis Valmor Portela3
1Translational Science on Brain Disorders, Clinical Neuroscience Laboratory, Department of Health and Behavior, Catholic University of Pelotas, Rua Gonçalves Chaves, 373-Sala 418C, CEP: 96015-560, RS, Brazil; Anhanguera College of Rio Grande, RS, Brazil.
Psychiatry Research
|June 19, 2019
Summary
Elevated levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) are linked to major depressive disorder (MDD) and bipolar disorder (BD). These cytokines may serve as biomarkers for mood disorders, indicating inflammatory involvement in their pathology.
Area of Science:
- Neuroscience
- Immunology
- Psychiatry
Background:
- Mood disorders like major depressive disorder (MDD) and bipolar disorder (BD) represent a significant global health burden.
- The role of inflammation in the pathophysiology of psychiatric disorders is an emerging area of research.
- Cytokines, such as IL-6 and IL-10, are key mediators of immune responses and inflammation.
Purpose of the Study:
- To investigate the association between serum levels of interleukin-6 (IL-6) and interleukin-10 (IL-10) and the presence of major depressive disorder (MDD) and bipolar disorder (BD).
- To explore the potential of these cytokines as biomarkers for mood disorders in a population-based sample.
Main Methods:
- A cross-sectional, population-based study involving 1037 young adults (aged 18-35).
- Assessment of MDD, BD, anxiety, and suicide risk using the Mini International Neuropsychiatric Interview.
- Quantification of serum IL-6 and IL-10 levels via ELISA.
Main Results:
- Individuals with MDD and BD exhibited significantly higher serum IL-6 and IL-10 levels compared to healthy controls (p ≤ 0.001).
- Covariance analysis indicated that mood disorders independently elevate IL-6 and IL-10 levels.
- No significant correlation was found between cytokine levels and suicide risk or anxiety disorders in the absence of mood disorders.
Conclusions:
- Inflammatory dysregulation, indicated by elevated IL-6 and IL-10, appears to be implicated in the physiopathology of MDD and BD.
- Serum IL-6 and IL-10 levels show promise as potential biomarkers for diagnosing and understanding mood disorders.
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