Related Experiment Video
Updated: Jan 23, 2026
07:12
Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
Published on: September 27, 2021
2.7K
Ocular Drug Delivery: A Special Focus on the Thermosensitive Approach
Simona Sapino1,2, Daniela Chirio3,4, Elena Peira5,6
1Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy. simona.sapino@unito.it.
Nanomaterials (Basel, Switzerland)
|June 19, 2019
Summary
Thermosensitive drug delivery systems enhance ophthalmic drug bioavailability by forming in situ gels. These systems reduce administration frequency, improving patient adherence for ocular disease treatments.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Biomaterials Science
Background:
- Ophthalmic drug bioavailability is limited by physiological barriers, necessitating frequent administration.
- Novel drug delivery systems are crucial for sustained drug concentration in ocular tissues.
- Thermosensitive systems offer a promising approach to overcome these limitations.
Purpose of the Study:
- To review thermosensitive drug delivery strategies for enhancing ophthalmic therapeutics.
- To discuss applications in topical and intraocular/periocular drug delivery.
- To summarize advancements in treating posterior segment ocular diseases.
Main Methods:
- Review of current literature on thermosensitive ophthalmic drug delivery systems.
- Analysis of in situ forming gel properties and mechanisms.
- Discussion of in vitro models for evaluating ophthalmic drug delivery systems.
Main Results:
- Thermosensitive gels increase drug bioavailability and residence time.
- In situ forming gels improve corneal adhesion and form drug reservoirs.
- Reduced administration frequency enhances patient compliance.
Conclusions:
- Thermosensitive drug delivery systems significantly improve ophthalmic therapeutic efficacy.
- These systems offer versatile applications for various ocular administration routes.
- Further development of these systems holds promise for improved ocular disease management.
Related Concept Videos
01:16Drug Delivery: Overview
755
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
755
01:18Drug Delivery: Enteral Route
1.7K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.7K
01:29Drug Delivery: Parenteral Route
1.6K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.6K
01:22Drug Delivery: Miscellaneous Routes
752
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
752
01:13Special Staining Techniques
1.2K
Specialized staining techniques play a vital role in microbiology by enabling the visualization of specific bacterial structures that remain undetectable with standard microscopy methods. These techniques not only enhance the structural visualization of bacterial cells but also provide critical insights into their pathogenicity and classification. Additionally, they support diagnostic and research endeavors in microbiology by identifying key bacterial features.Capsule Staining for Virulence...
1.2K
01:26Introduction to Special Senses
7.3K
Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
7.3K