Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Requirements for Human Life01:26

Requirements for Human Life

13.2K
The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
13.2K
Proteins: Dietary Sources and Requirements01:28

Proteins: Dietary Sources and Requirements

1.6K
Consuming animal-based products offers high-quality proteins that contain optimal levels and combinations of essential amino acids, crucial for tissue repair and growth. Foods like eggs, milk, fish, and most meats are a source of complete proteins. Legumes and cereals are abundant in proteins; however, they typically lack a full range of essential amino acids. As a result, they are considered incomplete protein sources. Some plant sources like soybeans, quinoa, and amaranth do contain complete...
1.6K
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

1.2K
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
1.2K
Global Climate Change01:50

Global Climate Change

28.8K
Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
28.8K
Inhaled Medications01:23

Inhaled Medications

764
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
764
Work Done During Volume Change01:17

Work Done During Volume Change

5.1K
In mechanics, work is done on an object when the force acting on it displaces the object. In thermodynamics, work done on a system can be estimated when the system's volume changes during any thermodynamic process.
Consider a gas confined to a cylinder fitted with a movable piston at one end. If the gas expands from volume V1 to volume V2, it exerts a force on the piston, such that the piston moves by a distance dr.
The work done by the gas on the piston can be expressed as
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary Artery Diameters in Children, Teenagers and Young Adults Derived from Quiescent Interval Slice Selective (QISS) Magnetic Resonance Angiography.

Pediatric cardiology·2026
Same author

Correction: How pain intensity and mental disorders shape chronic pain sick leave and quality of life in the general Spanish population.

Scientific reports·2026
Same author

Are genetically defined "metapopulations" self-evident in YHRD?

Forensic science international. Genetics·2026
Same author

Autoantibodies to IL-1Ra and PGRN in severe COVID-19 are associated with inflammation-induced hyperphosphorylated antigen isoforms.

Nature communications·2026
Same author

MatchY in practice: Factors influencing pedigree-based Y-STR match probabilities.

Forensic science international. Genetics·2026
Same author

Evaluation of the Prediction Potential of the HIrisPlex-S System in a North German Population.

Genes·2026
Same journal

Methods for incorporating test result information within the high-dimensional propensity score framework: application in UK electronic health record data.

BMC medical research methodology·2026
Same journal

Sparse multi-way DMDC for longitudinal classification in high dimension low sample size data.

BMC medical research methodology·2026
Same journal

Tree-based exploratory identification of predictive biomarkers in non-randomized data.

BMC medical research methodology·2026
Same journal

Comparative evaluation of interrupted time series analytical methods for healthcare quality improvement research: a Monte Carlo simulation study.

BMC medical research methodology·2026
Same journal

Methodological advances in claims-based dementia algorithms: integrating medication and clinical data for medicare populations.

BMC medical research methodology·2026
Same journal

An interpretable XGboost algorithm for predicting 30-day mortality in acute pancreatitis using routine biomarkers.

BMC medical research methodology·2026
See all related articles

Related Experiment Video

Updated: Jan 23, 2026

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

11.7K

Does big data require a methodological change in medical research?

Amke Caliebe1, Friedhelm Leverkus2, Gerd Antes3

  • 1Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany. caliebe@medinfo.uni-kiel.de.

BMC Medical Research Methodology
|June 19, 2019
PubMed
Summary
This summary is machine-generated.

Big data in medical research offers promise but requires careful methodology. Established principles of data analysis and interpretation remain crucial, emphasizing the need for prospective studies alongside big data approaches for robust evidence-based medicine.

Keywords:
Big dataCausalityCorrelationData qualityDigitalizationHypothesis generationScientific methodologyValidation

More Related Videos

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
11:21

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

8.6K
Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow
12:53

Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow

Published on: June 14, 2017

11.2K

Related Experiment Videos

Last Updated: Jan 23, 2026

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
12:39

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types

Published on: December 10, 2012

11.7K
Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
11:21

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

8.6K
Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow
12:53

Bidirectional Retroviral Integration Site PCR Methodology and Quantitative Data Analysis Workflow

Published on: June 14, 2017

11.2K

Area of Science:

  • Medical research
  • Data science
  • Philosophy of science

Background:

  • Big data is increasingly utilized in medical research, presenting unique challenges compared to traditional studies.
  • Digitalization generates vast datasets, offering potential for disease treatment, diagnosis, and prevention improvements.
  • Examining big data's specific characteristics is vital for maintaining evidence-based medicine principles.

Purpose of the Study:

  • To discuss the methodological challenges and opportunities of big data in medicine.
  • To highlight the importance of causality versus correlation in medical and commercial research.
  • To advocate for distinguishing exploratory data analysis from confirmatory hypothesis validation.

Main Methods:

  • Methodological review of big data in medical research.
  • Discussion on causality and correlation in data analysis.
  • Emphasis on the distinction between hypothesis generation and validation.

Main Results:

  • Big data presents both challenges and opportunities for medical research.
  • The distinction between exploratory and confirmatory analysis is critical.
  • Independent verification of results is increasingly important due to data quality issues.

Conclusions:

  • Established principles of data generation, analysis, and interpretation are essential in the big data era.
  • Big data analyses can benefit medical research but should complement, not replace, carefully designed prospective studies.